Yonsei University · Medicine
Professor Hyun Woong Lee's research lab specializes in hepatology and viral hepatitis, with a strong focus on antiviral therapies, liver fibrosis, and the development of novel treatments for hepatitis B and C. The lab investigates host and viral factors influencing treatment response, evaluates the role of repurposed drugs like statins and immunomodulators (e.g., Tα1), and explores natural compounds from medicinal herbs as potential anti-hepatitis C agents. The research also extends to liver cancer, particularly the use of selective internal radiation therapy (SIRT) in unresectable hepatocellular carcinoma.
Figures are computed from collected data and may differ slightly.
The lamivudine-induced virologic response was durable in patients under 40 years old and those receiving lamivudine for more than 12 months after HBeAg clearance or seroconversion. Age and additional treatment were major predictive factors for SVR.
In this large population-based study, statin use decreased the risk of NAFLD occurrence and the risk of liver fibrosis once NAFLD developed.
Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five co
Clinical factors including age, peak creatinine, bilirubin, ALT, initial LDH and total cholesterol were independent factors for s-AH in a multivariate analysis. In particular, HAV load strongly correlated with the severity of hepatitis A.
The combination treatment of Talpha1 and lamivudine did not have an obvious benefit of virological and biochemical response as compared to the lamivudine monotherapy during the combination period. In addition, after the cessation of Talpha1 treatment, the combination therapy did not prevent the occurrence of viral and biochemical breakthroughs.
SIRT was an effective treatment for unresectable HCC. Unilobar disease before SIRT and tumor response (CR/PR) were positive prognostic factors.
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