Sungkyunkwan University · Medicine
Professor Hyun-Sik Kang's research lab focuses on the intersection of lifestyle interventions, metabolic health, and aging, with a strong emphasis on how physical activity and exercise influence physiological outcomes across the lifespan. Key research directions include the impact of exercise on insulin resistance, metabolic syndrome, gut microbiota modulation, and the preservation of muscle and bone health in older adults. The lab also investigates the role of genetic factors—such as the *ACTN3* R577X genotype—in age-related decline and explores the protective effects of exercise preconditioning in critical illness models like sepsis.
Figures are computed from collected data and may differ slightly.
PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.
Procedure-related thromboembolic events occurred more frequently in patients in the upper quartile with higher PRU, especially in the fourth quartile. Further study including a large number of patients is expected to confirm this finding.
The current findings suggest that IR is significantly associated with the clustering of MetS risk factors in children in Korea.
Our findings suggest that the <i>ACTN3</i> R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults.
This study investigated the effects of exercise preconditioning-induced modification in gut microbiota composition and host responses to cecal ligation and puncture (CLP)-induced sepsis. Four-week-old C57BL/6N male mice were randomly assigned to either CLP ( n = 30) or CLP-exercise (CLP+Exe; n = 30) groups. Prior to CLP-induced sepsis, the CLP+Exe mice were subjected to 8 wk of treadmill running. Fecal samples were collected and analyzed by 16S rRNA amplification sequencing to assess gut microbi
The purpose of this study was to investigate the association between physical fitness and mild cognitive impairment (MCI) in elderly Koreans. This was a cross-sectional study that involved 134 men and 299 women aged 65 to 88 years. Six senior fitness tests were used as independent variables: 30 s chair stand for lower body strength, arm curl for upper body strength, chair-sit-and-reach for lower body flexibility, back scratch for upper body flexibility, 8-ft up-and-go for agility/dynamic balance
The current findings suggest that a multifaceted intervention targeting at promotion of physical activity and CRF in concert with healthy eating behaviors should be implemented as a preventive strategy against Mets in Korean university students.
PA was inversely and independently associated with all-cause mortality in Korean older adults.
The current findings suggest that the prognostic importance of depressive symptoms for all-cause mortality might be sex-specific in Korean older adults. Geriatr Gerontol Int 2018; 18: 950-956.
This study investigated the suppressive effect of exercise preconditioning against colitis induced by high-fat diet (HF) plus dextran sulfate sodium (DSS) in wild-type mice. Male mice (C57BL/6) aged 6 weeks were assigned to standard chow (SC, <i>n</i> = 10) or HF (<i>n</i> = 10) or HF followed by DSS (HF+DSS, <i>n</i> = 10) or exercise preconditioning (EX) followed by HF+DSS (EX+HF+DSS, <i>n</i> = 10) for a total of 15 weeks. After 12 weeks of dietary treatments and/or exercise preconditioning,
Background: The disadvantage of using body mass index (BMI) as an obesity diagnostic tool is that it cannot distinguish between fat mass and lean mass, which may understate the impact of obesity on metabolic complications. This population-based cross-sectional study aimed to investigate the relationship between normal-weight obesity (NWO) and metabolic syndrome in Korean adults aged 20 years (5962 males and 6558 females) who took part in the Korea National Health and Nutrition Examination Survey
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