Yonsei University · Medicine
Professor Ja Seung Koo's research lab focuses on the tumor microenvironment and metabolic reprogramming in breast cancer, with particular emphasis on amino acid and lipid metabolism, immune cell interactions, and metastatic progression. The lab investigates how cancer-associated stromal cells, including tumor-associated myeloid cells and cancer-associated adipocytes, contribute to tumor growth, immune evasion, and therapy resistance. By analyzing subtype-specific and metastatic site-specific metabolic alterations, the lab aims to identify novel therapeutic targets for aggressive breast cancer subtypes such as triple-negative and HER2-positive disease.
Figures are computed from collected data and may differ slightly.
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression. Breast cancer is the most common malignancy in women worldwide and is still associated with high mortality rates, despite improved treatment strategies. Recent studies have demonstrated that the amin
Lipid metabolism-related proteins are differentially expressed in different IHC subtypes of breast cancer and some are associated with decreased survival rates.
DSVPC is a major subtype of PTC in the young.
Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epidermal growth factor receptor 2 (HER-2)-positive breast cancer and triple-negative breast cancer, are solid tumors containing immune cell stroma. TAMCs drive breast cancer progression v
Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active participants in breast cancer progression and response to treatment through autocrine and paracrine interaction with the malignant cells. Adipose tissue is abundant in the breast cance
Different expression levels of lipid metabolism-related proteins were observed according to metastatic site. The expression of ACOX1 and FASN was highest in brain metastasis. These results suggest that the metastatic site should be considered when using lipid metabolism inhibitors for targeted therapy.
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