Yonsei University · Medicine
Professor Jae Hee Cho's research lab specializes in interventional endoscopy and minimally invasive therapies for gastrointestinal and hepatobiliary malignancies, with a focus on radiofrequency ablation (RFA) techniques for biliary and pancreatic cancers. The lab investigates temperature-controlled RFA, including endoscopic biliary RFA (EB-RFA) and intraductal RFA (ID-RFA), to improve treatment efficacy and safety in advanced or surgically challenging cases. A key research direction involves understanding molecular mechanisms of chemoresistance in pancreatic ductal adenocarcinoma, particularly the role of the NRF2 pathway in tumor progression and therapeutic resistance. The lab also contributes to clinical classification systems and procedural optimization in endoscopy, such as TNM staging for pancreatic neuroendocrine tumors and procedural sequencing in same-day endoscopy.
Figures are computed from collected data and may differ slightly.
EB-RFA using a temperature controlled RFA catheter successfully ablates the bile duct wall without adverse events in a swine model.
Temperature-controlled ID-RFA for advanced MHBO was safe and feasible. It could prevent premature PS occlusion within 3 months.
Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer and remains an obstacle to successful treatment. The antioxidant transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (NRF2), which plays important roles in tumor angiogenesis and invasiveness, is upregulated in pancreatic ductal adenocarcinoma (PDAC), where it correlates with poor survival. Here, we investigated the role of NRF2 in two 5-Fluourouracil-resistant (5-FUR) PDAC cel
The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.
EB-RFA partially ablated human cancer tissue and preoperative EB-RFA might be a safe and feasible in patients with distal extrahepatic cholangiocarcinoma who require a delayed operation. Ablation of the target lesion longer than the estimated length by fluoroscopy may improve the efficacy of EB-RFA.
The quality of EGD steps is influenced by the sequence of bidirectional endoscopy. EGD is perceived to be more stressful to patients when preceded by colonoscopy. Therefore, EGD followed by colonoscopy may be the preferable procedural sequence for same-day bidirectional endoscopy.
Our results suggest that the BRCA2 mutation may not contribute to increases in the risk for both sporadic and familial pancreatic cancer in Korea.
Pancreatic cancer stem cells (CSCs) play a crucial role in tumorigenesis and chemoresistance of pancreatic ductal adenocarcinoma. Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel secretory protein, has been shown to contribute to cancer progression and metastasis. Because the clinical relationship between PAUF and pancreatic CSCs is largely unknown, we investigated the associations between the functional role of PAUF and pancreatic CSCs. Pancreatic cancer sphere cultured from the CF
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