Seoul National University · Engineering
Professor Jae-Joon Kim's research lab focuses on advancing cancer therapeutics, particularly in challenging malignancies such as peritoneal carcinomatosis, triple-negative breast cancer, and head and neck squamous cell carcinoma. The lab investigates innovative immunotherapeutic strategies, including intraperitoneal immunotherapy and the role of the tumor microbiome in treatment response, aiming to overcome immunological tolerance and improve outcomes. Utilizing multi-omics approaches and advanced imaging techniques like ¹⁸F-FDG PET/CT, the lab seeks to identify predictive biomarkers and optimize therapeutic evaluation in clinical settings.
Figures are computed from collected data and may differ slightly.
The flowering time of plants is affected by modest changes in ambient temperature. However, little is known about the regulation of ambient temperature-responsive flowering by small RNAs. In this study, we show that the microRNA156 (miR156)-SQUAMOSA PROMOTER BINDING PROTEIN-LIKE3 (SPL3) module directly regulates FLOWERING LOCUS T (FT) expression in the leaf to control ambient temperature-responsive flowering. Overexpression of miR156 led to more delayed flowering at a lower ambient temperature (
Accurate transmission of biosignals without interference of surrounding noises is a key factor for the realization of human-machine interfaces (HMIs). We propose frequency-selective acoustic and haptic sensors for dual-mode HMIs based on triboelectric sensors with hierarchical macrodome/micropore/nanoparticle structure of ferroelectric composites. Our sensor shows a high sensitivity and linearity under a wide range of dynamic pressures and resonance frequency, which enables high acoustic frequen
This LC ring oscillator is an architectural experiment to reduce the phase noise of an LC oscillator even further with a ring type structure. An LC oscillator with a special ring type structure performs phase noise filtering and attenuation. To prove the concept, several LC-ring oscillators are fabricated in 0.6 /spl mu/m, single-poly, triple-metal, CMOS. The three-stage LC-ring oscillator has -132 dBc/Hz measured phase noise at 600 kHz offset frequency from a 900 MHz carrier.
The development of donor-specific HLA antibodies (DSA) is associated with worse renal allograft survival in adult patients. This study assessed the natural history of de novo DSA, and its impact on renal function in pediatric renal transplant recipients (RTR). HLA antibodies were measured prospectively using single-antigen-bead assays at 1, 3, 6 and 12 months posttransplant followed by 12-monthly intervals and during episodes of allograft dysfunction. Of 215 patients with HLA antibody monitoring
This paper presents a salient clock deskewing method with a mixed-mode delay-locked loop (MDLL) for high-speed synchronous DRAM applications. The presented method not only solves the resolution problem of conventional digital deskewing circuits, but also improves the jitter performance to the level of well-designed analog deskewing circuits, while keeping the power consumption and locking speed of digital deskewing circuits. The whole deskewing circuit is fabricated in a 3.3-V 0.6-/spl mu/m trip
Skin-interfaced electronics have emerged as a promising frontier in personalized healthcare. However, existing skin-interfaced patches often struggle to simultaneously achieve robust skin adhesion, adaptability to dynamic body motions, seamless integration of bulky devices, and on-demand, damage-free detachment. Here, a hybrid strategy that synergistically combines these critical features within a thin, flexible patch platform is introduced. This design leverages shape memory polymers (SMPs) arr
This study presents a flexible wireless electronic skin (e-skin) sensor system that includes a multi-functional sensor device, a triple-mode reconfigurable readout integrated circuit (ROIC), and a mobile monitoring interface. The e-skin device's multi-functionality is achieved by an interlocked micro-dome array structure that uses a polyvinylidene fluoride and reduced graphene oxide (PVDF/RGO) composite material that is inspired by the structure and functions of the human fingertip. For multi-fu
This study presents a novel, ultralow-power single-sensor-based electronic nose (e-nose) system for real-time gas identification, distinguishing itself from conventional sensor-array-based e-nose systems, whose power consumption and cost increase with the number of sensors. Our system employs a single metal oxide semiconductor (MOS) sensor built on a suspended 1D nanoheater, driven by duty cycling─characterized by repeated pulsed power inputs. The sensor's ultrafast thermal response, enabled by
The first examples of negative solvatochromism in neutral azo dyes containing both strongly electron-donating bis(dialkylamino)thiazolyl and electron-withdrawing 4-(trifluoromethylsulfonyl)phenyl or 2-thiazolyl moieties are reported.
Skin Electronics To overcome the physical limits of real life, realistic experiences and interactions in the virtual space are desirable, especially in the current pandemic situation. In article number 2009602, Jae Joon Kim, Yan Wang, and co-workers introduce the current advances in skin electronic devices. As a next-generation device platform, advanced on-skin electronics can replace the conventional bulky augmented reality and virtual reality devices, to yield highly immersive experiences.
Peritoneal metastasis, also known as peritoneal carcinomatosis (PC), is a refractory cancer that is typically resistant to conventional therapies. The typical treatment for PC is a combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Recently, research in this area has seen significant advances, particularly in immunotherapy as an alternative therapy for PC, which is very encouraging. Catumaxomab is a trifunctional antibody intraperitoneal (IP) immuno
(Dialkylamino)thiazole dimers act as very strong electron-donating coupling components in azo dyes, the first and second UV–VIS absorption bands of which were observed at λ = 568–737 (ε = 24000–88000) and 404–475 (ε = 9200–52000) nm in dichloromethane, respectively. The azo compounds derived from the (dialkylamino)thiazole dimers having very strong electron-withdrawing moieties such as 4-(perfluoroalkylsulfonyl)phenyls, 2,4-dinitrophenyl, and thiazol-2-yls exhibited a negative solvatochromism. T
The functional support and advancement of our body while preserving inherent naturalness is one of the ultimate goals of bioengineering. Skin protection against infectious pathogens is an application that requires common and long-term wear without discomfort or distortion of the skin functions. However, no antimicrobial method has been introduced to prevent cross-infection while preserving intrinsic skin conditions. Here, we propose an antimicrobial skin protection platform copper nanomesh, whic
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