Korea University · Engineering
Professor Jae Wook Lee's research lab focuses on regenerative medicine and immunotherapy, with a strong emphasis on mesenchymal stem cell therapy for lung injury and stroma-targeted cancer immunotherapy. The lab investigates mechanisms of tissue repair, including alveolar fluid clearance and antimicrobial activity, as well as the role of tumor microenvironment components like fibroblast activation protein (FAP) in cancer immunity. Their work bridges molecular biology, stem cell biology, and translational immunology to develop novel therapeutic strategies for inflammatory and malignant diseases.
Figures are computed from collected data and may differ slightly.
In E. coli-injured human lungs, mesenchymal stem cells restored alveolar fluid clearance, reduced inflammation, and exerted antimicrobial activity, in part through keratinocyte growth factor secretion.
An emphasis on exchange rate surveillance-a topic that has always been at the core of the IMF's mandate-received renewed impetus in the IMF's Medium-Term Strategy (MTS), 1 that called inter alia for stronger emphasis on multilateral surveillance, macrofinancial linkages, and the implications of globalization, reflecting the stronger economic ties among member countries brought about by the rapid increase in international trade and financial integration. The exchange rate analysis conducted by th
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTConvergent Synthesis of Symmetrical and Unsymmetrical PAMAM DendrimersJae Wook Lee, Byung-Ku Kim, Hee Joo Kim, Seung Choul Han, Won Suk Shin, and Sung-Ho JinView Author Information Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea, and Department of Chemistry Education & Center for Plastic Information System, Pusan National University, Busan 609-735, Korea Cite this: Macromolecules 2006, 39, 6, 2418–2422Publication Date (Web):
Murine studies have shown that immunologic targeting of the tumor vasculature, a key element of the tumor stroma, can lead to protective immunity in the absence of significant pathology. In the current study, we expand the scope of stroma-targeted immunotherapy to antigens expressed in tumor-associated fibroblasts, the predominant component of the stroma in most types of cancer. Mice were immunized against fibroblast activation protein (FAP), a product up-regulated in tumor-associated fibroblast
Iterative algorithms, like gradient descent, are common tools for solving a variety of problems, such as model fitting. For this reason, there is interest in creating differentially private versions of them. However, their conversion to differentially private algorithms is often naive. For instance, a fixed number of iterations are chosen, the privacy budget is split evenly among them, and at each iteration, parameters are updated with a noisy gradient.
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