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Jae Yeol Lee

Kyung Hee University · Chemistry

About the Lab

Professor Jae Yeol Lee's research lab specializes in organic materials chemistry and medicinal chemistry, with a focus on developing novel thermally activated delayed fluorescence (TADF) emitters for next-generation optoelectronic devices. The lab also investigates small molecule compounds with targeted anticancer mechanisms, particularly in non-small cell lung cancer, exploring their apoptotic pathways and synergistic effects with existing chemotherapeutics. The integration of advanced molecular design with biological evaluation defines the lab’s interdisciplinary approach to materials and drug discovery.

TADF emittersorganic semiconductorsanticancer agentsapoptosis mechanismmolecular design

Research Overview

Papers
344
Total Citations
4,772
Papers (5y)
42
Primary Field
Chemistry

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
42total
2021
2022
2023
2024
2025
Citations per year (5y)
117total
20212022202320242025

Selected Papers

15
1
Article|211 citations·2019
Antibacterial and antioxidant properties of hydroxypropyl methylcellulose-based active composite films incorporating oregano essential oil nanoemulsions
Jae Yeol Lee, Coralia V. Garcia, Gye Hwa Shin, Jun Tae Kim
SJR Q1FWCI 7.9LWT
BiomaterialsMaterials Science
2
Article|79 citations·1996
Geometric reasoning for knowledge-based parametric design using graph representation
Jae Yeol Lee, Kwang-Soo Kim
SJR Q1FWCI 7.0Computer-Aided Design
Industrial and Manufacturing EngineeringEngineering
3
Article|77 citations·1998
A feature-based approach to extracting machining features
Jae Yeol Lee, Kwangsoo Kim
SJR Q1FWCI 8.8Computer-Aided Design
Industrial and Manufacturing EngineeringEngineering
4
Article|67 citations·2007
Discovery of potent T-type calcium channel blocker
Han Na Seo, Ja Youn Choi, Yun Jeong Choe, Yoonjee Kim, Hyewhon Rhim, So Ha Lee, Jungahn Kim, Dong Jun Joo, Jae Yeol Lee
SJR Q2FWCI 1.5Bioorganic & Medicinal Chemistry LettersOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|59 citations·2008
T-type Ca2+ channel blockers suppress the growth of human cancer cells
Jae Ho Heo, Han Na Seo, Yun Jeong Choe, Sujin Kim, Chun Rim Oh, Young Deuk Kim, Hyewhon Rhim, Dong Joon Choo, Jungahn Kim, Jae Yeol Lee
SJR Q2FWCI 2.2Bioorganic & Medicinal Chemistry LettersOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|53 citations·2003
Network-centric feature-based modeling
Jae Yeol Lee, Soonhung Han, Hyun Kim, Sang Bong Park
FWCI 19.4

Network and Internet technology opens up another domain for building future CAD/CAM environments. The environment will be global, network-centric, and spatially distributed. We present an approach for network-centric feature-based modeling in a distributed design environment. The presented approach combines the current feature-based modeling technique with distributed computing and communication technology for supporting product modeling and collaborative design activities over the network. The

Industrial and Manufacturing EngineeringEngineering
7
Article|50 citations·2004
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers
Yong Sup Lee, Bum Hoon Lee, Seong Jun Park, Soon Bang Kang, Hyewhon Rhim, Jin-Yong Park, Jung‐Ha Lee, Seong‐Woo Jeong, Jae Yeol Lee
SJR Q2FWCI 3.0Bioorganic & Medicinal Chemistry LettersOA
Organic ChemistryChemistry
8
Article|45 citations·2012
Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists
Tae Woo Kim, Byoung Wook Yoo, Joon Kwang Lee, Joon Kwang Lee, Ji Han Kim, Kyung‐Tae Lee, Yong Ha, Jae Yeol Lee, Jae Yeol Lee
SJR Q2FWCI 2.8Bioorganic & Medicinal Chemistry LettersOA
Organic ChemistryChemistry
9
Article|45 citations·2014
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors
Kyung Ju Kim, Min Ji Choi, Ji‐Sun Shin, Minju Kim, Hye‐Eun Choi, Seoung Mook Kang, Jae Ho Jin, Kyung‐Tae Lee, Jae Yeol Lee
SJR Q2FWCI 3.7Bioorganic & Medicinal Chemistry LettersOA
PharmacologyMedicine
10
Article|44 citations·2011
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor
Han Byul Kang, Hong-Kun Rim, Jin Yeong Park, Heung Woo Choi, Doo Li Choi, Ji‐Hyung Seo, Kyung‐Sook Chung, Geun Huh, Jungahn Kim, Dong Joon Choo, Kyung‐Tae Lee, Jae Yeol Lee
SJR Q2FWCI 1.9Bioorganic & Medicinal Chemistry LettersOA
Organic ChemistryChemistry
11
Article|42 citations·2020
KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation
Jeong-Hun Lee, Hwi-Ho Lee, Ki Deok Ryu, Misong Kim, Dohyeong Ko, Kyung‐Sook Chung, Ahmed H.E. Hassan, Seung Hyeun Lee, Jae Yeol Lee, Kyung‐Tae Lee
SJR Q1FWCI 4.0Journal of Clinical MedicineOA

We previously reported that 4-(4-fluorobenzylcarbamoylmethyl)-3-(4-cyclohexylphenyl)-2-[3-(<i>N,N</i>-dimethylureido)-<i>N'</i>-methylpropylamino]-3,4-dihydroquinazoline (KCP10043F) can induce G<sub>1</sub>-phase arrest and synergistic cell death in combination with etoposide in lung cancer cells. Here, we investigated the underlying mechanism by which KCP10043F induces cell death in non-small cell lung cancer (NSCLC). Propidium iodide (PI) and annexin V staining revealed that KCP10043F-induced

Organic ChemistryChemistry
12
Article|42 citations·2004
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers
Hyewhon Rhim, Yong Sup Lee, Seong Jun Park, Bong Young Chung, Jae Yeol Lee
SJR Q2FWCI 2.7Bioorganic & Medicinal Chemistry LettersOA
Organic ChemistryChemistry
13
Article|37 citations·1997
Asymmetric synthesis of both enantiomers of novel tetracyclic heterocycle, furo[3′,2′:2,3]pyrrolo[2,1-a]isoquinoline derivative via a diastereoselective N-acyliminium ion cyclization
Jae Yeol Lee, Yong Sup Lee, Bong Young Chung, Hokoon Park
SJR Q3FWCI 3.3Tetrahedron
Organic ChemistryChemistry
14
Article|34 citations·2006
Synthesis and SAR studies of a novel series of T-type calcium channel blockers
Seong Jun Park, Sung Jun Park, Min Joo Lee, Hyewhon Rhim, Yoonjee Kim, Jung‐Ha Lee, Jung-Ha Lee, Bong Young Chung, Jae Yeol Lee, Jae Yeol Lee
SJR Q2FWCI 1.8Bioorganic & Medicinal Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
Article|34 citations·1999
Web-Enabled Feature-Based Modeling in a Distributed Design Environment
Jae Yeol Lee, Hyun Kim, Sung-Bae Han
FWCI 6.5

Abstract Network and Internet technology open up another domain for building future CAD/CAM environments. The environment will be global, network-centric, and spatially distributed. In this paper, we present Web-enabled feature-based modeling in a distributed design environment. The presented approach combines the current feature-based modeling technique with distributed computing and communication technology for supporting product modeling and collaborative design activities over the network. T

Industrial and Manufacturing EngineeringEngineering

Research Areas

Organic ChemistryMolecular BiologyPharmacologyIndustrial and Manufacturing EngineeringBiomaterialsInfectious Diseases

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