Kyung Hee University · Medicine
Professor Jae-Hong Ryoo's research lab specializes in metabolic and cardiovascular epidemiology, focusing on the interplay between metabolic disorders and chronic diseases. The lab investigates the predictive roles of non-alcoholic fatty liver disease (NAFLD), serum uric acid levels, and metabolic syndrome in the development of type 2 diabetes, hypertension, chronic kidney disease, and pancreatic cancer. Using large-scale prospective cohort studies in Korean populations, the lab aims to identify early biomarkers and risk factors for chronic disease progression.
Figures are computed from collected data and may differ slightly.
The development of type 2 DM is potentially more associated with more progressive NAFLD than a normal or milder state. In addition, NAFLD was an independent risk factor for the future development of type 2 DM. These results suggest the potential availability of NAFLD as an early predictor of type 2 DM.
Development of hypertension is more potentially associated with the more progressive NAFLD than normal or milder state. In addition, NAFLD was an independent risk factor for hypertension.
There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m(2). The odds ratio (OR)
MetS is a potential risk factor for pancreatic cancer. The presence of ≥4 metabolic components leads to a higher risk of pancreatic cancer even within categories of the MetS.
Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between NAFLD and prehypertension. A prospective cohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and C
Elevated serum UA level was independent risk factor for the development of microalbuminuria during a 5-year follow-up in Korean men.
Our findings show that serum γ-glutamyltransferase level could be a predictor of the development of insulin resistance in Korean men.
In this study, elevated ferritin concentration is independently associated with metabolic syndrome and its components among healthy Korean men.
Metabolic syndrome is a potential risk factor for cholelithiasis. Low HDL cholesterol level is the most relevant factor among MetS components for incident cholelithiasis.
In this study, apoB was found to be the most important determinant for the future development of CHD during a 5-year follow-up in healthy Korean men.
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