Korea University · Medicine
Professor Jae-Yong Park's research lab focuses on molecular mechanisms underlying cancer development and neurodegenerative disorders, with a particular emphasis on apoptosis-related genes, microRNAs, and signaling pathways. The lab investigates genetic polymorphisms (e.g., CASP-9, COX-2) and microbial dysbiosis (e.g., gastric microbiome) in relation to cancer susceptibility and progression. Additionally, the lab explores the role of key regulatory proteins such as 14-3-3γ in neural development and brain disorders, as well as the functional impact of alternative splicing isoforms like nCLU in cell death regulation. Their work integrates molecular biology, genomics, and bioinformatics to identify biomarkers and therapeutic targets for cancer and neurological diseases.
Figures are computed from collected data and may differ slightly.
Caspase-9 (CASP-9) is an initiator CASP in the apoptosome-driven apoptosis pathway and plays an important role in the development and progression of cancer. Polymorphisms in the promoter region of the CASP-9 gene may influence the promoter activity of this gene, thereby modulating susceptibility to lung cancer. To test this hypothesis, we examined the association of four polymorphisms [-1263A>G, -905T>G, -712C>T and -293_-275delCGTGAGGTCAGTGCGGGGA (-293del)] in the CASP-9 promoter with the risk
Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types. The pro-apoptotic CLU appears to be a nuclear isoform (nuclear clusterin; nCLU), and the secretory CLU (sCLU) is thought to be anti-apoptotic. The detailed molecular mechanism of nCLU as a pro-apoptotic molecule has not yet been clear. In the current study, overexpressed nCLU induced apoptosis in human kidney cells. Biochemical studies revealed that nCLU sequestered Bcl-
Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome during gastric carcinogenesis, and to predict the functional potentials of the microbiome involved in the cancer development. The gastric microbiome was analyzed using gastric juice samples from 88 prospectively enrolled patients, who were classified into gastritis, gastric adenoma, or early/
The six-step operation of surface-mounted permanent magnet machine drives in a flux weakening region has many advantages compared to the pulse width modulation mode, such as the reduced switching loss and fully utilized inverter output voltage. However, if the ratio of the sampling frequency to the fundamental frequency is low in fixed sampling system, the low-frequency oscillation in the current can be incurred in the six-step operation. The low-frequency current causes a system stability probl
These findings suggest that the COX-2 8473T>C polymorphism could be used as a marker for the genetic susceptibility to adenocarcinoma of the lung.
14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3γ is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the distinctive levels of temporally and locally regulated 14-3-3γ expression in various brain disorders suggest that it could play a substantial role in
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