Yonsei University · Medicine
Professor Jaeyong Shin's research lab focuses on translational biomedical research with an emphasis on aging, frailty, and regenerative therapies. The lab investigates natural bioactive compounds—such as ginseng polysaccharides—for their immunomodulatory and anti-cancer properties, particularly in macrophage function and cytokine regulation. It also explores innovative dermatological treatments, including fractional CO₂ laser and phototherapy for vitiligo, and examines the role of physical performance markers like hand grip strength in predicting health outcomes. Additionally, the lab contributes to the emerging field of healthcare applications of large language models, emphasizing methodological rigor in clinical AI research.
Figures are computed from collected data and may differ slightly.
The root of Panax ginseng C. A. Meyer is one of the most popular natural tonics in oriental countries. In this study, we have isolated polysaccharide fraction of Panax ginseng (ginsan) and examined its effect on the function of murine peritoneal macrophages. When macrophages were treated with ginsan, cytotoxic activity against B16 melanoma cells was significantly induced. In addition, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 a
This study suggests that fractional CO(2) laser therapy followed by NB-UVB phototherapy could be used effectively and safely as an alternative modality for the treatment of refractory vitiligo.
The findings of this cohort study suggest that a frailty index measured at 66 years of age was associated with accelerated acquisition of age-related conditions, disability, and death over the next 10 years. Measuring frailty at this age may offer opportunities to prevent age-related health decline.
The results of the current study strengthen the previous findings in regards to hand grip strength and health. Furthermore, the results of our study shines light on the necessity of considering individual differences in BMI, when using a physical measure as a study variable.
More research is required regarding the application of LLMs in healthcare. Although previous studies have evaluated performance, future studies will likely focus on improving performance. A well-structured methodology is required for these studies to be conducted systematically.
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CO(2) FL might be a very convenient and effective modality for treating IGH without significant side effects.
The objective of this study was to evaluate the effects of diabetes mellitus (DM) on the rate of carpal tunnel release (CTR) using a large nationwide cohort in Korea and to identify risk factors, including comorbidities and socioeconomic status (SES), associated with CTR. Patients with a primary or secondary diagnosis of carpal tunnel syndrome (CTS; ICD-10 code: G560) were selected and divided into two groups according to the presence of DM. A Cox proportional hazard model was used to assess the
Although we need to perform further investigations to determine the exact mechanisms, regional deprivation, as well as medical factors, might be associated with survival after onset of ischemic stroke in low-income patients.
OBJECTIVES: Mental health disorders and suicide are an important and growing public health concern in Korea. Evidence has shown that both globally and in Korea, obesity is associated with an increased risk of developing some psychiatric disorders. Therefore, we examined the association between distorted body weight perception (BWP) and suicidal ideation.\n\nMETHODS: Data were obtained from the 2007-2012 Korea National Health and Nutritional Evaluation Survey (KNHANES), an annual cross-sectional
This is a rare case of infectious keratitis caused by Verticillium species. Rare species of fungal infection should be considered in the differential diagnosis of stromal keratitis refractive to conventional medical treatment.
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