Jaeyun Kim

Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and a dye-doped mesoporous silica shell with a poly(ethylene glycol) coating (see picture of TEM images and schematic depictions). These nanoparticles can be used as magnetic resonance and fluorescence imaging agents, and as drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis and therapy. Detailed facts of importance to specialist readers are published as ”Supporting

Nanotechnology offers tremendous potential for future biomedical technology. Due to their unique characteristics including superparamagnetic or fluorescent properties, and small size comparable to biomolecules, nanostructured materials have emerged as novel bioimaging, diagnostic, and therapeutic agents for the future medical field. Especially, the combinations of various nanostructured materials with different properties can offer synergetic multifunctional nanomedical platforms, which make it

We synthesized uniform pore-sized mesoporous silica spheres embedded with magnetite nanocrystal and quantum dots. The magnetic separation, luminescent detection, and controlled release of drugs were demonstrated using the uniform mesoporous silica spheres embedded with monodisperse nanocrystals.

Nonnegative matrix factorization (NMF) determines a lower rank approximation of a matrix $A \in \mathbb{R}^{m \times n} \approx WH$ where an integer $k \ll \min(m,n)$ is given and nonnegativity is imposed on all components of the factors $W \in \mathbb{R}^{m \times k}$ and $H \in \mathbb{R}^{k \times n}$. NMF has attracted much attention for over a decade and has been successfully applied to numerous data analysis problems. In applications where the components of the data are necessarily nonnega

Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with gold nanoshells embedded with Fe 3O4 nanoparticles. The Fe3O4 nanoparticles allow magnetic resonance imaging (MRI) for diagnosis, and the gold nanoshells enable photothermal therapy. By attaching an antibody to the Mag-GNS by a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Multifunctional polymer nanomedical platforms make simultaneous cancer-targeted MRI or optical imaging together with efficient drug delivery in vitro possible. In addition, clusters of Fe3O4 nanoparticles loaded in the polymer nanoparticles endow the magnetic guiding of the polymer particles, providing synergetic targeting efficiency. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2008/c1726_s.pdf or from the author. Please note: Th

For the practical use of synthetic hydrogels as artificial biological tissues, flexible electronics, and conductive membranes, achieving requirements for specific mechanical properties is one of the most prominent issues. Here, we demonstrate superstrong, superstiff, and conductive alginate hydrogels with densely interconnecting networks implemented via simple reconstructing processes, consisting of anisotropic densification of pre-gel and a subsequent ionic crosslinking with rehydration. The re

Abstract Transdermal drug delivery patches based on hydrogels are widely used for the transdermal delivery of diverse drugs. However, most hydrogels do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive hydrogels consisting of polyacrylamide/polydopamine (PAM/PDA) hydrogels embedded with extra‐large pore mesoporous silica nanoparticles (XL‐MSNs) are proposed based on the synergy of cohesive and adhesive properties. The incorporation of XL‐MSNs leads to enhanced strength a

Sequential decoration of silica spheres by covalent bonding of magnetite nanoparticles (blue) and attachment of functional nanoparticles of Au, CdSe/ZnS, or Pd (red) afforded multifunctional assemblies exhibiting combinations of magnetism with surface plasmon resonance (Au), luminescence (CdSe/ZnS), and catalytic activity (Pd), respectively.

Immunotherapy has been recognized for decades as a promising therapeutic method for cancer treatment. To enhance host immune responses against cancer, antigen-presenting cells (APCs; e.g., dendritic cells) or T cells are educated using immunomodulatory agents including tumor-associated antigens and adjuvants, and manipulated to induce a cascading adaptive immune response targeting tumor cells. Mesoporous silica materials are promising candidates to improve cancer immunotherapy based on their att

Cancer vaccine aims to invoke antitumor adaptive immune responses to detect and eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have several limitations that are mostly derived from the <i>ex vivo</i> culture of patient DCs. To circumvent the limitations, direct activation and maturation of host DCs using antigen-carrying materials, without the need for isolation of DCs from patients, are required. In this study, we demonstrate the synthesis of extra-large pore

Although reactive oxygen species (ROS) are essential for cellular processes, excessive ROS could be a major cause of various inflammatory diseases because of the oxidation of proteins, DNA, and membrane lipids. It has recently been suggested that the amount of ROS could thus be regulated to treat such physiological disorders. A ROS-scavenging hydrogel is a promising candidate for therapeutic applications because of its high biocompatibility, 3D matrix, and ability to be modified. Approaches to c

Krebs im Visier: Multifunktionelle magnetische Gold-Nanoschalen (Mag-GNS) entstehen beim Beschichten von Siliciumoxid-Kugeln mit Gold-Nanoschalen, in die Fe3O4-Nanopartikel eingelagert sind. Die Fe3O4-Nanopartikel ermöglichen eine kernspintomographische Diagnose (MRI) und die Gold-Nanoschalen eine photothermische Therapie. Nach Anbinden eines Antikörpers an die Mag-GNS über einen Polyethylenglycol(PEG)-Linker lassen sich Krebszellen gezielt ansteuern. Supporting information for this article is a

Dendritic cells (DCs) are antigen-presenting cells that play an important role in connecting the innate and adaptive immunity of the immune system. To mediate innate and adaptive immunity, DCs pass through two stages: immature and mature. The change of phenotype is closely associated with the morphological and functional characteristics of DCs. Understanding these properties of DCs is important in the context of recent efforts on the developments of biomaterials-based cancer vaccine. In this pap