Sungkyunkwan University · Medicine
Professor Jeong Hoon Yang's research lab specializes in critical care and cardiovascular medicine, with a primary focus on understanding and improving outcomes in patients with severe circulatory failure. The lab investigates the pathophysiology of heart failure with preserved ejection fraction (HFpEF), particularly coronary microvascular dysfunction and its impact on diastolic function and prognosis. A significant portion of the research is dedicated to evaluating the role and timing of mechanical circulatory support, including ECMO and extracorporeal cardiopulmonary resuscitation (ECPR), in patients with refractory shock and cardiac arrest. The lab emphasizes patient selection, prognostic factors, and the integration of hemodynamic and clinical markers to guide life-saving interventions.
Figures are computed from collected data and may differ slightly.
Coronary microvascular dysfunction is common in patients with HFpEF and is caused equally by endothelium-dependent and independent mechanisms, but the presence of microvascular dysfunction cannot be identified from clinical markers and co-morbidities alone. Patients with HFpEF and endothelium-independent microvascular dysfunction display worse diastolic dysfunction and outcomes.
Survival to hospital discharge remained low in adult patients with refractory septic shock despite ECMO support. Our findings suggest that implantation of ECMO during refractory septic shock could be considered in patients with severe myocardial injury but should be avoided in patients who have received CPR.
Survival rate for ECPR in the setting of OHCA remains poor. Our findings suggest that ECMO implantation should be very carefully considered in highly selected patients who had OHCA with little no-flow time and a reversible cause.
The in-hospital mortality of patients with CS remains high despite the high utilization of mechanical circulatory support. Age, low body mass index, cardiac arrest at presentation, amount of vasopressor, and advanced organ failure requiring various support devices were poor prognostic factors for in-hospital mortality. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02985008.
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