Sungkyunkwan University · Medicine
Professor Jeongmi Lee's research lab specializes in green and sustainable extraction technologies for natural products, with a focus on optimizing extraction processes for pharmaceutical and biochemical applications. The lab investigates novel metabolic pathways in microorganisms, particularly alternative polyamine biosynthesis in pathogens like *Vibrio cholerae*, and explores the enzymatic mechanisms of beta/alpha-barrel fold decarboxylases in diverse bacteria. Additionally, the lab conducts metabolomic and antioxidant profiling of natural products—such as green tea—under varying preparation conditions to understand how processing parameters influence bioactive compound profiles and functional properties.
Figures are computed from collected data and may differ slightly.
Green and efficient extraction of natural products from biomass is considered an important area of interest in the pharmaceutical and biochemical industries.
Polyamines are small organic cations found in all cells, and the biosynthetic pathway is well described in eukaryotes and Escherichia coli. The characterized pathway uses decarboxylated S-adenosylmethionine as the aminopropyl group donor to form spermidine from putrescine by the key enzymes S-adenosylmethionine decarboxylase and spermidine synthase. We report here the in vivo characterization of an alternative polyamine biosynthetic pathway from Vibrio cholerae, the causative agent of human chol
The beta/alpha-barrel fold type basic amino acid decarboxylases include eukaryotic ornithine decarboxylases (ODC) and bacterial and plant enzymes with activity on L-arginine and meso-diaminopimelate. These enzymes catalyze essential steps in polyamine and lysine biosynthesis. Phylogenetic analysis suggests that diverse bacterial species also contain ODC-like enzymes from this fold type. However, in comparison with the eukaryotic ODCs, amino acid differences were identified in the sequence of the
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