Seoul National University · Medicine
Professor Jeongmin Seo's research lab focuses on the biological and molecular mechanisms underlying the health benefits of lactic acid bacteria, particularly *Lactobacillus plantarum* strains, with a strong emphasis on their postbiotic components such as exopolysaccharides (EPS). The lab investigates how these microbial metabolites modulate immune responses, metabolic regulation, and cellular signaling pathways—including TLR2 and AMPK—offering therapeutic potential for obesity, metabolic syndrome, and cancer. Using integrative approaches combining cell biology, live-cell imaging, and in vivo models, the lab explores how dietary bioactive compounds like DHA influence subcellular protein localization and membrane dynamics, contributing to metabolic and inflammatory disease prevention. The research bridges microbiology, immunology, and metabolic disease, aiming to translate microbial-derived molecules into functional foods and clinical interventions.
Figures are computed from collected data and may differ slightly.
Inflammation is a biological response of the immune system to defend the body from negative stimulation. However, the excessive inflammatory response can damage host tissues and pose serious threats. Exopolysaccharide (EPS), one of the postbiotics, is secreted from lactic acid bacteria. Although many studies have described the beneficial effects of EPS, such as its anti-inflammatory and anti-oxidant effects, its underlying mechanisms have remained to be poorly understood. Thus, we identified tha
EPS from L-14 extract inhibits adipogenesis via TLR2 and AMPK signalling pathways, and oral intake of L-14 extract improves obesity and obesity-associated diseases in vivo. Therefore, EPS can be used to prevent and treat obesity and metabolic disorders.
Membrane localization of lipidated cytosolic signaling proteins is mediated by interactions between specific lipid anchors and membranes, but little is known about the regulatory role of membrane composition in lipidated protein membrane targeting. Here, using green fluorescent protein (GFP) chimeras and quantitative fluorescence microscopy in living mouse colonocytes, we show that docosahexaenoic acid (DHA), a dietary polyunsaturated fatty acid (PUFA) with membrane lipid-modifying properties, s
These results indicate that metabolic syndrome patients without hypertension may have decrease of myocardial systolic and early diastolic velocities on tissue Doppler imaging, even if they appear to have normal systolic and diastolic function on conventional echocardiography.
Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. <i>Lactobacillus plantarum</i> (<i>L. plantarum</i>), a species of lactic acid bacteria (LAB), is being studied for human health, including cancer treatment. However, few studies have elucidated the relationship between <i>L. plantarum</i> extract and human malignant melanoma. To investigate the effects of <i>L. plantarum</i> on
Obesity and associated metabolic disorders, including cardiovascular disease and diabetes, are rapidly becoming serious global health problems. It has been reported that <i>Lactobacillus plantarum</i> (<i>L. plantarum</i>) extracts have the beneficial activities of antiobesity and antidiabetes, although few studies have compared the beneficial effects among various <i>L. plantarum</i> extracts. In this study, three new <i>L. plantarum</i> (named LP, LS, and L14) strains were identified, and the
Hyaline cartilage is a tissue of very low regenerative capacity because of its histology and limited nutrient supply. Cell-based therapies have been spotlighted in the regeneration of damaged cartilage. Dental pulp stem cells (DPSCs) are multipotent and are easily accessible for therapeutic purposes. In human gastrointestinal tracts, <i>Enterococcus faecium</i> is a naturally occurring commensal species of lactic acid bacteria. In this work, the human DPSCs were differentiated into chondrocytes
Cell-penetrating peptides (CPPs) are defined by their ability to deliver cargo into cells and have been studied and developed as a promising drug-delivery system (DDS). However, the issue of whether the CPPs that have already entered the cells can be re-released or reused has not been studied. The purpose of this research was to construct CPP-conjugated human fibroblast growth factor 2 (hFGF2) and investigate whether they can be re-released from the cell membrane for reuse. This study combined h
Cell-penetrating peptides (CPPs) are short amino acid sequences known to act as a vehicle for enhancing the intracellular translocating efficiency of extracellular molecules. Although many groups have attempted to develop peptides with high cell-penetrating efficiencies, very few have demonstrated efficient cellular uptake of CPPs at low concentrations. Here, we describe a newly synthesized peptide derived from Arabidopsis, Ara-27, which exhibits significant improvement in cell-penetrating effic
In proton therapy, the spot scanning method is known to suffer from the interplay effect induced from the independent movements of the proton beam and the organs in the patient during the treatment. To study the interplay effect, several investigators have performed four-dimensional (4D) dose calculations with some limited temporal resolutions (4 or 10 phases per respiratory cycle) by using the 4D computed tomography (CT) images of the patient; however, the validity of the limited temporal resol
방사선 치료에서 일정한 호흡주기의 유지가 필요한 흉부 및 복부를 치료할 때 환자의 자세와 belly board device의 사용 여부에 따라 다르게 나타나는 호흡신호의 차이를 통계적으로 분석하여 임상적용에 관한 유용성을 검정하였다. 호흡주기유지는 supine 자세에서 비교적 양호하게 나타났으며, prone 자세에서 호흡주기 유지가 양호하지 않은 경우에 belly board를 적용하여 85%가 유의하게 다른 패턴의 호흡주기를 보였고, 57%는 호흡주기 유지가 양호하게 변화한 것으로 나타났다. 각 피험자의 비만도와 체중에 따른 호흡주기유지 안정성의 차이는 보이지 않았으며, 안정성의 상대적 비교지수로 분석한 시간의 흐름에 따른 호흡의 안정성 유지는 supine 자세에서 비교적 안정적이었으며, 호흡주기 유지의 검정통계결과와 일치하였다(p=0.044, kappa=0.607). 흉부 및 복부 심지어 골반의 방사선치료에서도 호흡에 의한 환자의 움직임은 중요한 고려사항 중 하나이다. 환자의 치료
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