Kyung Hee University · Medicine
Professor Ji Ho Park's research lab specializes in nanomedicine and neuropharmacology, focusing on the cellular and molecular mechanisms of nanoparticle trafficking in biological systems and their therapeutic applications. The lab investigates neuroactive compounds such as curcumin and EGCG for their roles in modulating neural plasticity, cognitive function, and neuroprotection. Additionally, the lab explores natural bioactive compounds—like those from Korean red pine bark and green tea—for their potential in treating neurodegenerative and cardiovascular diseases. The integration of advanced neurophysiological techniques with in vivo and ex vivo models underpins the lab’s translational research approach.
Figures are computed from collected data and may differ slightly.
Engineered nanoparticles that can be injected into the human body hold tremendous potential to detect and treat complex diseases. Understanding of the endocytosis and exocytosis mechanisms of nanoparticles is essential for safe and efficient therapeutic application. In particular, exocytosis is of significance in the removal of nanoparticles with drugs and contrast agents from the body, while endocytosis is of great importance for the targeting of nanoparticles in disease sites. Here, we review
Nitric oxide (NO) is recognized as a signaling molecule in the CNS where it is a candidate retrograde neurotransmitter. Here we provide direct evidence that NO mediates slow excitatory anterograde transmission between the NO synthase (NOS)-expressing B2 neuron and an NO-responsive follower neuron named B7nor. Both are motoneurons located in the buccal ganglia of the snail Lymnaea stagnalis where they participate in feeding behavior. Transmission between B2 and B7nor is blocked by inhibiting NOS
Curcumin is a major diarylheptanoid component of <i>Curcuma longa</i> with traditional usage for anxiety and depression. It has been known for the anti-inflammatory, antistress, and neurotropic effects. Here we examined curcumin effect in neural plasticity and cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor the effect of 10 <i>μ</i>M curcumin in long-term depression (LTD) through low-frequency stimulation (LFS) to the Schaf
Automatic abusive language detection is a difficult but important task for online social media. Our research explores a twostep approach of performing classification on abusive language and then classifying into specific types and compares it with one-step approach of doing one multi-class classification for detecting sexist and racist languages. With a public English Twitter corpus of 20 thousand tweets in the type of sexism and racism, our approach shows a promising performance of 0.827 Fmeasu
Korean red pine (<i>Pinus densiflora</i> Sieb. et Zucc.) bark is a by-product of the wood industry and contains a high level of antioxidative phenolics including flavonoids, which have a variety of beneficial health effects. This study aimed to investigate the antihypertensive effects of <i>P. densiflora</i> bark extract (Korean red pine bark extract; KRPBE) in spontaneously hypertensive rats (SHRs). A group of Wistar-Kyoto rats (WKRs) as a normotensive group was orally fed tap water. Four group
Epigallocatechin gallate (EGCG) is a major flavan-3-ol of green tea polyphenols that exhibits various beneficial health effects, including antioxidant, anti-bacterial, and anti-inflammatory properties. This study aimed to evaluate whether EGCG prevents scopolamine-induced learning and memory impairment in <i>in vivo</i> and <i>ex vivo</i> models. Male Sprague-Dawley (SD) rats were pre-treated with EGCG (5 mg/kg/day; intraperitoneal injection (i.p.)) for 10 days. Then, EGCG and scopolamine (1 mg/
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