Yonsei University · Medicine
Professor Ji Hoe Heo's research lab specializes in cerebrovascular pathophysiology, with a focus on microvascular integrity, extracellular matrix remodeling, and thrombus composition in acute ischemic stroke. The lab investigates the role of matrix metalloproteinases (MMPs) in blood-brain barrier disruption and vascular damage during cerebral ischemia, using advanced imaging and molecular techniques. A key research direction involves understanding thrombosis mechanisms in stroke patients with cancer, particularly the pro-thrombotic characteristics of thrombi in active malignancy. The lab also explores interventional strategies, such as abciximab use, to restore perfusion after thrombolytic reocclusion. These studies aim to improve outcomes in acute stroke through a deeper understanding of vascular and thrombotic pathology.
Figures are computed from collected data and may differ slightly.
Microvascular integrity is lost during focal cerebral ischemia. The degradation of the basal lamina and extracellular matrix are, in part, responsible for the loss of vascular integrity. Matrix metalloproteinases (MMPs) may play a primary role in basal lamina degradation. By using a sensitive modification of gelatin zymography, the authors investigated the activity of MMP-2 and MMP-9 in frozen 10-microm sections of ischemic and nonischemic basal ganglia and plasma samples of 27 non-human primate
Microvascular integrity is lost during cerebral ischemia. Detachment of the microvascular basement membrane (BM) from the astrocyte, as well as degradation of the BM, is responsible for the loss of microvascular integrity. However, their ultrastructural and temporal changes during cerebral ischemia are not well known. Male Sprague-Dawley rats were subjected to permanent middle cerebral artery occlusion (MCAO) for 1, 4, 8, 12, 16, 20, and 48 hr. By using transmission electron microscopy, the prop
Immediate reocclusion after successful thrombolysis was angiographically examined in 29 consecutive stroke patients. The reocclusion, which was associated with a high-grade residual stenosis of initially perfused arteries, occurred in four patients. IV abciximab successfully dissolved the thrombus in all four patients. Rapid thrombotic reocclusion after successful thrombolysis is commonly observed in patients after an acute stroke. Administration of abciximab may lead to reperfusion of the reocc
The histological features of thrombus in stroke patients with cancer are not well known. Using immunohistochemical staining of thrombi retrieved during mechanical thrombectomy in stroke patients, thrombus compositions were compared between 16 patients with active cancer, 16 patients with inactive cancer, and 16 patients without any history of cancer. The active cancer group showed higher platelet and lower erythrocyte fractions than the inactive cancer or the control group. Four patients with ve
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