Sungkyunkwan University · Biochemistry, Genetics and Molecular Biology
Professor Ji Hye Kim's research lab focuses on molecular mechanisms underlying skin health, aging, and cancer progression, with a strong emphasis on identifying bioactive compounds from natural sources—particularly ginseng derivatives—for therapeutic and cosmetic applications. The lab investigates signaling pathways involved in inflammation, oxidative stress, and autophagy, as well as the regulatory roles of microRNAs and epigenetic enzymes such as PRMTs in disease development. Key research directions include the development of ginseng-derived nanoformulations and natural compounds for skin protection and anti-aging, and exploring their molecular targets in cancer and metabolic diseases. The lab integrates molecular biology, cell signaling, and translational research to advance cosmeceutical and pharmaceutical applications.
Figures are computed from collected data and may differ slightly.
Protein arginine methyltransferases (PRMTs) mediate the methylation of a number of protein substrates of arginine residues and serve critical functions in many cellular responses, including cancer development, progression, and aggressiveness, T-lymphocyte activation, and hepatic gluconeogenesis. There are nine members of the PRMT family, which are divided into 4 types (types I-IV). Although most PRMTs do not require posttranslational modification (PTM) to be activated, fine-tuning modifications,
These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).
This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng<b>.</b> In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.
SYR showed antioxidant activity and up-regulated autophagy activity in H<sub>2</sub>O<sub>2</sub>-stimulated HaCaT cells, lowering the expression of MMP-2 and MMP-9 associated with skin aging. Our results suggest that SYR has potential value as a cosmetic additive for prevention of skin aging.
PPT improves skin barrier function and hydration through Src/AKT/NF-κB and MAPK signaling. Therefore, PPT may be a valuable component for cosmetics or treating skin disorders.
Several studies have reported reduced miR-199a-3p expression in hepatocellular carcinoma (HCC). In an effort to discover important target genes for miR-199a-3p that may be related to HCC development or progression, we identified the tetraspanin, transmembrane glycoprotein CD151. Luciferase reporter assays and western blotting identified CD151 as a bona fide miR-199a-3p target gene. While CD151 protein was increased in the mesenchymal but not the epithelial HCC cell lines, CD151 knockdown with si
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