Ji‐Heung Kim

When multiple intermolecular interactions occur simultaneously, complexed molecules undergo gelation by inter-cohesive bonding, inducing a pseudo-crosslinking effect to form a supramolecular gel. Among the number of substances that can induce supramolecular assembly, phenolic species such as 3,4-dihydroxy-l-phenylalanine (DOPA) are widely utilized for synthesizing adhesive materials. However, despite the strong adhesion capability of monomeric phenol, it lacks cohesive strength and rarely forms

Poly(ethylene glycol-b-lactide) possessing a methoxy group at the poly(ethylene glycol) (PEG) chain end and a polymerizable methacryloyl group at the poly(lactic acid) (PLA) chain end (MeO–PEG/PLA–methacryloyl) was prepared by an anionic ring-opening polymerization of ethylene oxide and DL-lactide in tandem manner initiated with a potassium 2-methoxyethanolate, followed by end-capping with an excess of methacrylic anhydride. The molecular weight of the obtained polymer was controlled by the init

Abstract The catechol functional group of dopamine (3,4‐dihydroxyphenethylamine) has the ability to form strong adhesive bonds to inorganic and organic surfaces in aqueous environments. In this study, novel adhesive polyaspartamides containing catechol pendant groups were synthesized from polysuccinimide through successive aminolysis reactions with quantitative dopamine and ethylenediamine. The adhesion and crosslinking of dopamine‐modified polyaspartamide in aqueous alkaline media was used succ

Abstract Novel thermo‐ and pH‐responsive hydrogels based on amphiphilic polyaspartamides possessing a lower critical solution temperature (LCST) and a volume‐phase transition were prepared and characterized. The polyaspartamide derivatives were synthesized from polysuccinimide, which is the polycondensate of L ‐aspartic acid monomer, through successive ring‐opening reactions using hydrophobic 2‐diisopropylaminoethylamine and hydrophilic ethanolamine. The amphiphilic copolymer was then crosslinke

Abstract Biodegradable polymers and the hydrogels have been increasingly applied in a variety of biomedical fields and pharmaceutics. α,β‐Poly( N ‐2‐hydroxyethyl‐ DL ‐aspartamide), PHEA, one of poly(amino acid)s with hydroxyethyl pendants, are known to be biodegradable and biocompatible, and has been studied as an useful biomaterial, especially for drug delivery, via appropriate structural modification. In this work, hydrogels based on PHEA were prepared by two‐step reaction, that is, the crossl

Abstract Novel amphiphilic, thermo‐ and pH‐responsive polyaspartamides showing both double‐responsive (pH and temperature) behavior and a sol‐gel transition were prepared and characterized. The polyaspartamide derivatives were synthesized by the successive aminolysis reactions of polysuccinimide using both hydrophobic N ‐alkylamine (laurylamine, octylamine, hexylamine) and hydrophilic N ‐isopropylethylenediamine. The composition of each component was analyzed by 1 H NMR. At the intermediate comp