Kyushu University · Engineering
Professor Jin Miyawaki's research lab specializes in the development and application of advanced carbon nanomaterials, particularly single-walled carbon nanohorns (SWNHs), for biomedical and environmental applications. The lab focuses on functionalizing SWNHs for drug delivery, in vivo imaging, and targeted diagnostics by incorporating magnetic or luminescent nanoparticles such as magnetite and Gd₂O₃. Key research directions include the quantitative biodistribution analysis of nanomaterials in living organisms, the stabilization of ultrafine nanoparticles within nanohorn cavities through confinement effects, and enhancing gas adsorption properties via controlled micropore hydration. The lab also explores the use of SWNHs as nanoreactors for high-temperature transformations, demonstrating their potential in materials synthesis and energy-related applications.
Figures are computed from collected data and may differ slightly.
We extensively investigated in vitro and in vivo the toxicities of as-grown single-walled carbon nanohorns (SWNHs), a tubular nanocarbon containing no metal impurity. The SWNHs were found to be a nonirritant and a nondermal sensitizer through skin primary and conjunctival irritation tests and skin sensitization test. Negative mutagenic and clastogenic potentials suggest that SWNHs are not carcinogenic. The acute peroral toxicity of SWNHs was found to be quite low--the lethal dosage for rats was
Nanoparticles of superparamagnetic magnetite have been strongly attached to single-walled carbon nanohorns (SWNHs) by using a simple method, namely the deposition of iron acetate clusters on SWNHs followed by heat treatment. The attached magnetite nanoparticles induce remarkable darkening of the magnetic resonance images, which allowed in vivo visualization (see figure) of the accumulative behavior of SWNHs in the spleen and kidneys. Supporting information for this article is available on the WW
Single-walled carbon nanohorns (SWNHs) are single-graphene tubules that have shown high potential for drug delivery systems. In drug delivery, it is essential to quantitatively determine biodistribution and ultrastructural localization. However, to date, these determinations have not been successfully achieved. In this report, we describe for the first time a method that can achieve these determinations. We embedded Gd(2)O(3) nanoparticles within SWNH aggregates (Gd(2)O(3)@SWNHag) to facilitate
The methane adsorption of water-preadsorbed carbons of different micropore widths w at 303 K was measured. Although the amount of adsorption of supercritical methane on microporous carbon at 303 K was less than 9.4 mg g-1 at 101 kPa, the presence of the preadsorbed water enhanced noticeably the methane adsorption at 303 K even under subatmospheric pressure. The adsorption increment of methane reached a maximum at 1−2 h after introduction of methane and decreased gradually to a steady value after
The large diameter of single-wall carbon nanohorns (SWNHs) allows various molecules to be easily incorporated in hollow nanospaces. In this report, we prove that the nanospaces of SWNHs even work as the chemical reaction field at high temperature; that is, Gd-acetate clusters inside SWNHs were transformed into ultrafine Gd(2)O(3) nanoparticles with their particle size retained even after heat-treatment at 700 degrees C. This indicates that the confinement of the Gd-acetate clusters in a deep pot
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