Ewha Womans University · Biochemistry, Genetics and Molecular Biology
Professor Jinheung Kim's research lab specializes in bioinorganic and coordination chemistry, with a focus on non-heme iron and nickel complexes for catalytic transformations and sustainable energy applications. The lab investigates reaction mechanisms of metal-peroxide systems, particularly those involving Fe(TPA) and Ni(pbt/pbi) complexes, to understand fundamental pathways in C–H activation, alkane functionalization, and CO₂ reduction. A key emphasis is placed on developing selective, earth-abundant catalysts for green chemistry, including light-driven CO₂ conversion and ion sensing using fluorescent probes. Advanced spectroscopic and mass spectrometric techniques are employed to characterize short-lived intermediates and elucidate mechanistic details.
Figures are computed from collected data and may differ slightly.
Catalytic alkane functionalization by the Fe(TPA)/tBuOOH system (with [Fe(TPA)Cl2]+ (1), [Fe(TPA)Br2]+ (2), and [Fe2O(TPA)2(H2O)2]4+ (3) as catalysts; TPA = tris(2-pyridylmethyl)amine) has been investigated in further detail to clarify whether the reaction mechanism involves a metal-based oxidation or a radical chain autoxidation. These two mechanisms can be distinguished by the nature of the products formed, their dependence on O2 (determined from argon purge and 18O2 labeling experiments), and
Based on EPR, Raman, and mass spectral evidence, the formula 1 best describes the transient intermediate which forms upon treatment of 2 with tert-butyl hydroperoxide in the presence of alcohol. Kinetic evidence suggests that its decomposition by oxidation of the bound alcohol proceeds via the transition state 3. tpa = tris(2-pyridylmethyl)amine.
The efficient and selective light-driven conversion of carbon dioxide to formate is a scientific challenge for green chemistry and energy science, especially utilizing visible-light energy and earth-abundant catalytic materials. In this report, two mononuclear Ni(II) complexes of pyridylbenzimidazole (pbi) and pyridylbenzothiazole (pbt), such as Ni(pbt)(pyS)<sub>2</sub> (<b>1</b>) and Ni(pbi)(pyS)<sub>2</sub> (<b>2</b>) (pyS = pyridine-2-thiolate), were prepared and their reactivities studied. T
A homogeneous assay is reported using Ru(phen)(2)(dppz)(2+) and a K(+)-binding aptamer for the selective and sensitive detection of a target oligonucleotide and potassium ions, based on reduction in fluorescence emission according to the formation of the G-quadruplex structure from the aptamer in the presence of K(+).
The selective assay of aluminum and cyanide ions is reported using fluorescence enhancement and quenching of a phenol–naphthol based chemosensor (PNI) in aqueous and nonaqueous solvents, respectively.
Strategies have been developed to obtain electrospray ionization mass spectral data on short-lived intermediates derived from the reactions of non-heme iron complexes with peroxides. The molecular composition of a transient green intermediate generated from [Fe(2)O(5-Me(3)-TPA)(2)(OH)(H(2)O)](ClO(4))(3) with H(2)O(2) in CH(3)CN at -40 degrees C was determined by introducing the solution via a precooled syringe to the inlet of the mass spectrometer. The observation of prominent ion clusters in bo
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