Ewha Womans University · Medicine
Professor Jinkwon Kim's research lab specializes in clinical and translational cardiovascular and cerebrovascular research, focusing on identifying novel biomarkers and hemodynamic parameters that predict outcomes in acute stroke and cardiovascular disease. The lab investigates the prognostic value of routine laboratory markers—such as red blood cell distribution width (RDW), brachial-ankle pulse wave velocity (baPWV), and serum alkaline phosphatase—and hemodynamic parameters like interarm blood pressure differences in predicting mortality, functional outcomes, and long-term prognosis after acute ischemic stroke. The lab also explores the impact of medical therapies, such as high-intensity statin use, on post-stroke outcomes, emphasizing the integration of clinical data with predictive modeling and robust algorithm development for risk stratification. Their work bridges basic biomarker science with real-world clinical application to improve patient outcomes in cerebrovascular and cardiovascular diseases.
Figures are computed from collected data and may differ slightly.
Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality. A total of 847 consecutive patients with first-ever acute cerebral infarction who presented to the emergency department within seven days of symptom onset were enr
The proposed algorithm shows effective accuracy performance with a short learning time. In addition we ascertained the robustness of the proposed algorithm by evaluating the entire MIT-BIH arrhythmia database.
After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.
Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is unknown. We evaluated the prognostic value of baPWV in 1765 patients who had been admitted for acute ischemic stroke and had completed measurement of baPWV during admission. Primary outcomes were all-c
Background and Purpose— Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known. Methods— In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes
The presence of interarm systolic or diastolic blood pressure difference ≥ 10 mm Hg is a strong independent prognostic marker in acute ischemic stroke.
The purpose of this research is to develop an intuitive and robust realtime QRS detection algorithm based on the physiological characteristics of the electrocardiogram waveform. The proposed algorithm finds the QRS complex based on the dual criteria of the amplitude and duration of QRS complex. It consists of simple operations, such as a finite impulse response filter, differentiation or thresholding without complex and computational operations like a wavelet transformation. The QRS detection pe
Hypertension is the single most important risk factor for hemorrhagic stroke, a leading cause of mortality and disability worldwide. Adherence to antihypertensive medication is essential to achieving strict blood pressure control, but poor adherence is common in clinical practice. We evaluated adherence to antihypertensive medication in patients with acute hemorrhagic stroke and its effects on long-term outcome. This was a retrospective cohort study based on a nationwide health insurance claims
Stroke patients are at high risk of developing pneumonia, which is major cause of post-stroke mortality. Proton pump inhibitors and H2 receptor antagonists are anti-ulcer drugs, which may predispose to the development of pneumonia by suppression of the gastric acid with bactericidal activity. Unlike proton pump inhibitors and H2 receptor antagonists, mucoprotective agents have gastroprotective effects with no or less anti-acid property. We aimed to investigate effects of the acid-suppressive med
baPWV has an independent prognostic value for predicting functional outcome after acute cerebral infarction. The prognostic value did not differ according to the stroke subtype.
In this nested case-control study using real-world data, treatment with pioglitazone exhibited significant cardiovascular preventive effect in diabetic patients with acute ischemic stroke.
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