Nagoya University · Engineering
Professor Jiro Kasahara's research lab focuses on the molecular mechanisms of neuronal signaling, particularly the roles of calcium/calmodulin-dependent protein kinases (CaMKs) in synaptic plasticity and memory formation. The lab investigates the activation dynamics and regulatory mechanisms of CaMKIV and CaMKII in hippocampal neurons, emphasizing their involvement in long-term potentiation (LTP) and CREB phosphorylation. Additionally, the lab explores high-speed combustion phenomena, including steady-state detonation around hypersonic projectiles in hydrogen-oxygen mixtures, using advanced optical diagnostics. These diverse interests reflect a strong focus on signal transduction in the nervous system and fluid dynamics in extreme conditions.
Figures are computed from collected data and may differ slightly.
The importance of well characterized calcium/calmodulin-dependent protein kinase (CaMK) II in hippocampal long term potentiation (LTP) is widely well established; however, several CaMKs other than CaMKII are not yet clearly characterized and understood. Here we report the activation of CaMKIV, which is phosphorylated by CaMK kinase and localized predominantly in neuronal nuclei, and its functional role as a cyclic AMP-responsive element-binding protein (CREB) kinase in high frequency stimulation
journal article
journal article
How to generate a steady-state detonation around a hypersonic projectile in stoichiometric hydrogen-oxygen premixed gases is studied. The speed of the hypersonic projectiles was beyond the Chapman ‐Jouguet(C‐J) detonation speed. The e owe eld around the projectile was visualized by using a gate intensie ed charge-coupled device camera(single-frame schlieren picturesand OHradical self-emissionimages ). Threeparameters are varied:1 ) the projectile e ight length from diaphragm rupture location, 2
Calcium/calmodulin-dependent protein kinases (CaM kinases) are major multifunctional enzymes that play important roles in calcium-mediated signal transduction. To characterize their regulatory mechanisms in neurons, we compared glutamate-induced phosphorylation of CaM kinase IV and CaM kinase II in cultured rat hippocampal neurons. We observed that dephosphorylation of these kinases followed different time courses, suggesting different regulatory mechanisms for each kinase. Okadaic acid, an inhi
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