Yonsei University · Medicine
Professor Jong Soo Lee's research lab specializes in clinical and translational studies in ophthalmology, urology, and hematology, with a focus on improving surgical outcomes and understanding disease mechanisms. Key research directions include optimizing refractive surgery through implantable collamer lens technology, enhancing robotic prostatectomy techniques for better functional recovery, and investigating the impact of body composition on prostate cancer prognosis. The lab also explores molecular mechanisms in hemoglobin switching, particularly the role of transcription factors like EKLF in globin gene regulation, aiming to inform gene therapy strategies for hemoglobinopathies.
Figures are computed from collected data and may differ slightly.
연구는 한국 지방정부들이 지향하는 혁신패턴, 주요 정책행위자와 환경요인을 분석하고 이들 간의 매개관계를 분석하고자 한다. 한국의 지방정부들이 지향하는 혁신패턴은 민주성, 효율성, 형평성, 유연성의 순으로 구성된 것으로 나타났다. 지방정부 혁신의 추진력은 단체장과 공무원에 의해 지배된다. 그러나, 이들의 혁신지향성을 제공하는 원천은 주민참여이다. 재정자립도는 전체 혁신성과 약한 부의 관계를 가지고 있으나, 재정자립도가 높은 지방정부일수록 민주성 제고 혁신시책에는 관심을 가지고 있다. 인구규모, 도농차이는 유의미한 영향을 미치지 못하며, 혁신에 대한 영향력의 경로는 혁신패턴별로 다르게 나타나고 있음이 밝혀졌다.
Implantable collamer lens implantation to correct myopia was an effective and safe surgery with high predictability and stability during long-term follow up. Slight myopic shift and cataract formation related with change in vault should be further evaluated.
SGLT2i improved a composite of all-cause mortality, DCGF, or serum creatinine doubling in KTRs. SGLT2i can be used safely and have beneficial effects on preserving graft function in diabetic KTRs.
In this Korean population, after multiple adjustment, IOP was found to decrease with age and to increase with BMI in men.
Based on propensity score matching with multiple variables and a large case series, Retzius sparing robot-assisted radical prostatectomy can be a candidate for future robot-assisted radical prostatectomy. It achieves better early continence recovery, a short operative time and early recovery compared to conventional robot-assisted radical prostatectomy.
Our CT results may help clinical ophthalmologists to accurately assess enlargement of the extraocular muscles and the optic nerve as well as aiding in the evaluation of exophthalmos.
Corneal endothelial cell density significantly decreased and the coefficient of variation in cell size significantly increased for high-risk PDR patients undergoing phacoemulsification, in contrast to normal persons at the postoperative 6 months.
This study examined the influence of age, sex, blood pressure, and obesity index on intraocular pressure (IOP), in order to investigate the relationship between the upper limits of the following two conditions in the general Korean population: the "systolic or diastolic hypertensive and obese" group and the "systolic or diastolic hypotensive and lean" group. A total of 6828 healthy subjects (13,656 eyes) underwent automated multi-phasic tests, including tonometry, blood pressure, visual field, a
This study investigated the toxicity of commercial non-steroid anti-inflammatory drug (NSAID) eye solutions against corneal epithelial cells in vitro. The biologic effects of 1/100-, 1/50-, and 1/10-diluted bromfenac sodium, pranoprofen, diclofenac sodium, and the fluorometholone on corneal epithelial cells were evaluated after 1-, 4-, 12-, and 24-hr of exposure compared to corneal epithelial cell treated with balanced salt solution as control. Cellular metabolic activity, cellular damage, and m
Patients with a subcutaneous fat index of 39.9 cm<sup>2</sup>/m<sup>2</sup> or greater at the diagnosis of castration resistant prostate cancer showed higher progression-free and cancer specific survival rates than those with a subcutaneous fat index of less 39.9 cm<sup>2</sup>/m<sup>2</sup> at diagnosis. The subcutaneous fat index determined by computerized tomography data could serve as a useful objective prognostic factor to discuss patient therapeutic options. Further studies are needed to d
CMC and HA, used in artificial tear formulation, could be utilized without any significant toxic effect on HCECs. Both significantly stimulated HCEC reepithelialization of corneal wounds.
Thermal massage was effective in improving dry eye syndrome both subjectively and objectively. It was safe and seems to be a useful treatment option.
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