Korea University · Medicine
Professor Jong-Hoon Kim's research lab focuses on regenerative medicine and cellular differentiation, particularly in neural lineage commitment from human embryonic stem cells. The lab investigates the role of extracellular matrix proteins, such as vitronectin, in enhancing oligodendrocyte differentiation, with implications for treating neurodegenerative diseases. Additionally, the lab develops advanced fluorescent probes for real-time detection of biologically relevant molecules like cysteine in live cells and tissues, supporting cancer research and diagnostics. The integration of stem cell biology with molecular imaging defines the lab’s interdisciplinary approach.
Figures are computed from collected data and may differ slightly.
Hyponatremia, especially serum levels <or=130 mmol/L, may indicate the existence of severe complications associated with liver cirrhosis.
Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.
We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that
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