The University of Tokyo · Medicine
Professor Jun Fujishiro's research lab specializes in translational pharmacology and surgical innovation, focusing on immunomodulatory therapies for organ transplantation and postoperative outcomes in pediatric surgery. The lab investigates novel S1P receptor modulators like KRP-203 for long-term graft survival and explores the clinical impact of surgical interventions such as abdominal drainage in pediatric complicated appendicitis. Additionally, the lab contributes to renal gene therapy and neuropharmacological models, aiming to bridge preclinical findings with clinical applications.
Figures are computed from collected data and may differ slightly.
Background. We demonstrate the long-term effectiveness of KRP-203 treatment in combination with a subtherapeutic dose of cyclosporine A (CsA) on rat renal allografts. Methods. We tested the effect of KRP-203 in combination with CsA using a rat skin allograft model. The Pharmacokinetic interaction between CsA and KRP-203 was evaluated. The selectivity of KRP-203 for sphingosine-1-phosphate (S1P)1 and S1P3 receptors were investigated in vitro. Heart rate alteration following bolus injection of pho
Objective: The aim of the study was to investigate the effect of abdominal drainage at appendectomy for complicated appendicitis in children. Summary of Background Data: Although an abdominal drain placement at appendectomy is an option for reducing or preventing postoperative infectious complication, there is controversy regarding its effect for complicated appendicitis. Method: The study used the data on appendectomies for complicated appendicitis in children (≤15 years old) that were operated
This study suggested that an abdominal drain placement at appendectomy for complicated appendicitis among children has no advantage and can be harmful for preventing postoperative complications.
This study generated new information about in vivo and ex vivo gene transfer into the kidney, which would be useful for renal gene therapy.
While D-HB was frequently observed in infants with CHD, the majority of D-HB cases resolved spontaneously in ≤1 week. Neonatal clinical parameters or CHD status was not predictive of D-HB. D-HB lasting >1 week in infants with CHD should be evaluated for the cause.
We examined the effects of two noradrenergic tricyclic antidepressants and two selective serotonin re-uptake inhibitors in the tail suspension test, with a suspension period of 30 min instead of the usual 10 min. Within the first 10 min, desipramine, nortriptyline and fluvoxamine significantly reduced the duration of immobility. Whereas desipramine and nortriptyline were also efficacious in the rest of the test period, fluvoxamine was not. Fluoxetine showed no significant effect throughout the s
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