Nagoya University · Biochemistry, Genetics and Molecular Biology
Professor Jun Kikuchi's research lab specializes in plant metabolomics, focusing on the dynamic analysis of metabolic pathways using advanced nuclear magnetic resonance (NMR) techniques. The lab employs stable isotope labeling—particularly 13C and 15N—combined with multidimensional hetero-nuclear NMR to trace the real-time movement of carbon and nitrogen in living plants. Key research directions include understanding stress responses, such as ethanol stress in Arabidopsis thaliana, and monitoring metabolic reprogramming during seed germination. The lab pioneers non-invasive, in vivo metabolic profiling to uncover the molecular mechanisms underlying plant development and stress adaptation.
Figures are computed from collected data and may differ slightly.
Nuclear magnetic resonance (NMR) will become a key technology in plant metabolomics with the use of stable isotope labeling and advanced hetero-nuclear NMR methodologies. To demonstrate the power of this approach, we performed multi-dimensional hetero-nuclear NMR analysis of metabolic movement of carbon and nitrogen nuclei in Arabidopsis thaliana. First, distinct ethanol-stress response was investigated using (13)C-labeled wild type and an ethanol-hypersensitive mutant plants. Furthermore, we fo
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