Sungkyunkwan University · Medicine
Professor Jung-Han Kim's research lab specializes in thyroid cancer biology and clinical oncology, with a focus on understanding the molecular mechanisms underlying cancer progression, particularly metastasis and lymph node involvement. The lab investigates key regulators such as matrix metalloproteinase-9 (MMP-9) and the effects of natural compounds like berberine on cancer cell invasion. They also develop predictive tools such as nomograms to personalize risk assessment for central lymph node metastasis in papillary thyroid cancer (PTC), aiming to improve clinical decision-making. Additionally, the lab explores the impact of patient-related factors like BMI and body surface area on tumor characteristics and surgical outcomes.
Figures are computed from collected data and may differ slightly.
Invasion of cancer cell induced by matrix metalloproteinase-9 (MMP-9) is one of pivotal steps in cancer metastasis. Herein, we investigated how cell invasion was regulated by berberine (BBR), an isoquinoline derivative alkaloid compound, in MDA-MB-231 human breast cancer cells. The basal level of MMP-9 activity and expression was dose-dependently increased by TNF-alpha, while TNF-a-induced MMP-9 gelatinase activity and expression was decreased by BBR. To investigate regulatory mechanism of TNF-a
We recommend the use of our nomogram to enable clinicians and patients to easily personalize and quantify the probability of CLNM during the both pre- and postoperative period. Clinicians may consider the prophylactic CND and meticulous postoperative evaluation in PTC patients with a high nomogram score. J. Surg. Oncol. 2017;115:266-272. © 2016 Wiley Periodicals, Inc.
The occurrence of chyle leakage after central compartment dissection even without lateral neck dissection was not rare, but was easily controlled with conservative management. Surgical management should be considered if the drainage amount does not decrease by >50% of the original amount of the day of detection after 2 days of NPO.
In women with PTC, higher BMI was an independent predictor for multiplicity and ETE. Furthermore, higher BSA was an independent predictor for multiplicity. However, BMI and BSA were not predictors for the PTC behavior in men.
The new gel pad LUS method significantly enhances the visualization of vocal cords in patients who have diffuse thyroid cartilage calcification interrupting LUS and, therefore, the overall efficacy of LUS as a perioperative diagnostic tool for VCP.
Prophylactic central neck dissection could be considered in 2.0 to 4.0 cm PTC with positive BRAF mutation. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1203-E1209, 2016.
File system integrity is very important to a system security, because it affects all users that share system files. Therefore, file system integrity tool (FIT) is widely used for host based file system monitoring. Recently, virtualization technology is applied to several computing areas such as server virtualization and cloud computing, and increasingly demands for a FIT. However, previous virtual machine FITs are not suitable for virtual machines, because its structure is insufficient to real-t
Factors affecting patient satisfaction after ARCR differed according to age. Psychological improvement was more important to elderly patients, whereas restoration of function was more important to younger patients. Pain relief was important for both age groups. Level of evidence: III.
Volatile flavor components of Codonopsis lanceolata were extracted by gas co-distillation (GCD), solvent extraction/fractionation (SEF), and headspace sampling (HSS) methods. The extracts were analyzed by dual-capillary gas chromatography-retention index (GC-RI) and gas chromatography-mass spectrometry(GC-MS). The two extracts prepared by SEF and HSS gave more similar fragrance to the Codonopsis lanceolata than the GCD extract. The GC profiles of the SEF and HSS extracts were similar to each oth
The essential oils from ripe fruit peel and leaf of Zanthoxylum piperitum DC were extracted by gas co-distillation method and analyzed by gas chromatography/mass spectrometry (GC/ MS) and retention index matching. The experimental results revealed the presence of over 100 volatile components. Major components were 1,8-cineol (25.47%), limonene (11.91%), geranyl acetate (9.01%), myrcene (6.15%) in fruit peel and citronellal (23.11%), 1,8-cineol (18.38%), citronellol (6.04%) in leaf. Among the com
Dear Editor, Gastrointestinal metastasis from lung carcinoma is usually asymptomatic [1]. Due to the rarity of pleomorphic lung cancer, there have been only a few reports regarding symptomatic gastrointestinal metastasis from pulmonary pleomorphic carcinoma [2], [3]. Herein, we report a case of recurrent intussusception caused by multiple metastases of pulmonary pleomorphic carcinoma, with the hope that our experience will aid readers in clinical decision-making. A 63-year-old male visited the e
Recently, the prevalence of large interactive surfaces renewed interests in windowing systems because of the advantages of enabling concurrent applications. We present the NEMOSHELL windowing system for multi-user interactive surfaces. We developed the system based on the Wayland system, a replacement for the Linux X. NEMOSHELL is designed to support multiple simultaneous applications, legacy input devices, legacy applications, and dynamic user interfaces. Finally, our demonstrations illustrate
An effective network layer which reduces cluster file system complexity is definitely needed in cluster computing environments where more than thousands of nodes are connected on a variety of different networks. Therefore, widely used cluster file systems such as Lustre, PVFS2, and GlusterFS provide networking virtualization layer. Through networking virtualization layer, each node accesses other nodes using a single interface over a variety of networks. However, previous networking virtualizati
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