Yonsei University · Dentistry
Professor Jung-Seok Lee's research lab specializes in regenerative dentistry and oral tissue engineering, with a primary focus on alveolar bone and periodontal regeneration. The lab investigates the efficacy of various bone graft materials—such as rhGDF-5, DBBM, DPBM, and rhBMP-2—in preserving and reconstructing alveolar ridge volume following tooth extraction or in compromised sites. Key research directions include optimizing grafting techniques, evaluating long-term clinical outcomes, and advancing digital and clinical measurement methods for periodontal parameters.
Figures are computed from collected data and may differ slightly.
rhGDF-5/beta-TCP has a greater potential to support the regeneration of the periodontal attachment. Long-term studies are necessary to confirm the uneventful maturation of the regenerated tissues.
DBBM and DPBM can comparably augment damaged extraction sockets with minimal postoperative reduction of the grafted volume. However, the large variations in the results should be further evaluated for application in routine dental clinics.
Buccal-bone-deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rhBMP-2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.
The results suggested that DPBM might produce comparable bone formation and volumetric stability with DBBM in maxillary sinus grafting, however, further clinical study with longer-term periods and larger sample sizes should be needed for confirming this suggestion.
In conclusion, the findings of this study suggest that NIs could be used safely for narrow alveolar ridges or narrow mesiodistal spaces on the basis of their high survival rate.
This study aimed to compare the accuracy and reliability of digital versus conventional clinical measurements of the width of keratinized tissue. To this end, the keratinized tissue width was measured at 110 tooth sites in 5 pig jaws. The measurements were made at each site using three-dimensional (3D) scanned images and a periodontal probe. The actual keratinized tissue width was subsequently measured on histologic slides prepared from the same sites, and differences between the histologic slid
Comparable histologic bone formation was found in both socket grafted groups with DBBM or DPBM covered by collagen membranes in periodontally damaged extraction sockets. However, a wide variation in new bone formation was found after 4 months of postsurgical healing and a tendency of higher new bone formation was shown at damaged sockets that had an intact unilateral residual wall regardless of buccal or lingual side.
In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.
Straumann tissue-level dental implants showed low failure rates and can be considered a useful long-term treatment option. The length, placement site, and insertion torque might affect implant survival.
Using a three-dimensionally printed surgical template with a nonmetal sleeve in the partial edentulous ridge resulted in larger deviations in implants placed in the mandible or distal free-end third or fourth nearest site.
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