Seoul National University · Medicine
Professor Jung-Won Suh's research lab focuses on cardiovascular and vascular biology, with a particular emphasis on the interplay between genetic factors, drug metabolism, and vascular calcification in cardiovascular disease. The lab investigates pharmacogenomic interactions—such as those involving CYP3A5 and clopidogrel—highlighting individualized responses to antiplatelet therapy. It also explores the role of medial arterial calcification, including breast arterial calcifications, as a marker and potential contributor to systemic vascular disease. Additionally, the lab examines endothelial dysfunction in hypertension and the protective effects of statins through mechanisms involving caveolin-1 and nitric oxide signaling.
Figures are computed from collected data and may differ slightly.
People with the CYP3A5 non-expressor genotype are vulnerable to drug interactions between clopidogrel and CYP3A inhibitors. This phenomenon may be associated with worse outcomes in patients with the non-expressor genotype who are given clopidogrel after coronary angioplasty and implantation of bare-metal stents.
Breast arterial calcifications (BAC), frequently observed on screening mammography, have been considered as an incidental finding without increased risk for breast cancer. They are medial calcifications and therefore, are indicative of arteriosclerosis. Previous studies indicated that the risk factors of BAC partly overlap with those of cardiovascular disease (CVD), and the presence of BAC is associated with prevalent and incident CVD. This suggests that medial arterial calcification might contr
Hypertension is associated with endothelial dysfunction and increased cardiovascular risk. Caveolin-1 regulates nitric oxide (NO) signaling by modulating endothelial nitric oxide synthase (eNOS). The purpose of this study was to examine whether HMG-CoA reductase inhibitor improves impaired endothelial function of the aorta in spontaneous hypertensive rat (SHR) and to determine the underlying mechanisms involved. Eight-week-old male SHR were assigned to either a control group (CON, n=11) or a ros
본 연구가 주목한 엄마대학원생은 엄마와 대학원생의 역할을 동시에 수행하는 여성으로 그동안 학문적으로 알려진 바가 매우 제한적이었다. 이에 대해연구는 엄마대학원생들의 학업 - 육아 양립의 경험을 심층적으로 탐구하고자현상학적 연구를 수행하였다. 그 결과 엄마대학원생은 제한된 시간과 물리적 힘을두고 대학원생의 역할과 엄마의 역할이 경합하는 역할갈등을 경험한다는 것을발견하였다. 엄마대학원생은 우선, 대학원생인 엄마로서 생산과 재생산의 딜레마, 우울감과 자격지심, 모성비난과 자책감을 경험한다. 또 자녀를 보육시설에맡기고 공부를 할 수 밖에 없는 상황에 대해 주변으로부터 받는 나쁜 엄마라는모성비난과 자신의 욕심 때문에 자녀를 희생시킨다는 자책감도 공부하는 엄마이기 때문에 겪게 되는 경험으로 나타났다. 다음, 엄마인 대학원생으로서 대학원동료와 교수의 이해부족을 대면하게 되고, 대학원과 어린이집이라는 상이한시간체계를 살고, 엄마대학원생의 젠더수행이 고려되지 않은 공간에서 모성성의소외를 경험한다.
Retrospectively registered at ClinicalTrials.gov on October 29, 2019 ( NCT04142268 ).
Come, let's to bed, </br> Says Sleepy-head; </br> Tarry a while, says Slow: </br> Put on the pan, </br> Says Greedy Nan, </br> Let's sup before we go. </br> — Traditional nursery rhyme Iwas brought up in an English boarding school whose attitudes and initiations were dedicated to
Rosuvastatin is associated with high on-treatment platelet reactivity compared with atorvastatin following the coadministration of clopidogrel for six months. Further studies are therefore warranted to clarify the mechanism underlying this relationship.
It is not clear if anti-restonotic effect of cilostazol is consistent for different types of drug-eluting stents (DES).The purpose of this study was to compare the anti-proliferative effect of cilostazol between DAT and TAT with consideration of confounding influences of DES type.Nine hundred and fifteen patients were randomized to either dual antiplatelet therapy (DAT; aspirin and clopidogrel) or triple antiplatelet therapy (TAT; aspirin, clopidogrel, and cilostazol) in the previous CILON-T tri
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