Keio University · Medicine
Professor Kazuno Negishi's research lab specializes in retinal neurophysiology and ophthalmic optics, focusing on the neural mechanisms underlying visual processing in the retina and the optical performance of intraocular lenses (IOLs). The lab investigates how neurotransmitters such as catecholamines modulate retinal horizontal cells, particularly in fish models, to understand neuromodulation in retinal circuits. Additionally, the lab examines longitudinal chromatic aberration in IOL materials and its impact on retinal image quality, aiming to improve clinical outcomes in cataract surgery. These interdisciplinary studies bridge cellular neuroscience and biophotonics to advance visual function restoration.
Figures are computed from collected data and may differ slightly.
The effects of catecholamines (CA) and certain related compounds in the superfusate were examined on the intracellularly recorded potential from horizontal cells in the fish (Eugerres plumieri) retina. The stimulated retinal area consisted of a central spot 1.0 mm in diameter and an annulus 2.0 mm in inner diameter and 4.0 mm in outer diameter; both forms of monochromatic stimuli were centered relative to the recording microelectrode. Each of the CA (dopamine, noradrenaline, and adrenaline) prod
Our results showed that longitudinal chromatic aberrations of some IOLs may degrade the quality of the retinal image. Attention must be paid to the detailed optical performance of IOL materials to achieve good visual function.
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