Kyoto University · Medicine
Professor Kazuo Chin's research lab specializes in sleep medicine and respiratory physiology, with a primary focus on obstructive sleep apnea syndrome (OSAS) and its systemic complications. The lab investigates the impact of OSAS on metabolic and coagulation profiles, particularly examining biomarkers such as leptin, fibrinogen, and inflammatory markers, and evaluates the therapeutic benefits of non-invasive ventilation like NCPAP. Research also explores the epidemiological links between OSAS, metabolic syndrome, and cardiovascular risk, especially in relation to circadian patterns and treatment outcomes. The lab integrates clinical studies with ultrasound-guided interventions to improve diagnostic accuracy and patient safety in regional anesthesia.
Figures are computed from collected data and may differ slightly.
Correction of sleep disordered breathing by NCPAP may be used to reduce VFA in OSAS patients. OSAS may have significant effects on the serum leptin levels.
Needle visualization is important for safe and successful ultrasound-guided peripheral nerve block. However, accurate and consistent visualization of the needle tip can be difficult to achieve. This review article describes many of the challenges affecting needle visualization, summarizes the relevant literature on ultrasound imaging of needles, and offers practical strategies for improving needle tip visibility. Finally, future directions for research and development are suggested.
In patients with obstructive sleep apnea syndrome (OSAS), the blood coagulation system may contribute to an increased risk of cardiovascular events, which occur most frequently in the morning. Nasal continuous positive airway pressure (NCPAP) treatment can improve the mortality of patients with OSAS. We measured the plasma fibrinogen concentration, which is an independent risk factor for cardiovascular events, in the afternoon (3:30 P.M.) and the next morning upon awakening (8:30 A.M.) in 11 pat
Although increased BMI and age both had a significant effect on the prevalence of OSA in patients with Mets, one of 6 subjects with Mets, but only one of 40 without Mets had severe OSA in an urban male population in Japan. Physicians should take into account this high prevalence of severe OSA in patients with Mets. Sleep duration should be taken into consideration as an important factor in studies investigating the prevalence of severe OSA and Mets.
The prevalence of sleep disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence of obstructive sleep apnea (OSA) is higher than previously believed, with patients having moderate-to-severe OSA accounting for approximately 20% of adult males and 10% of postmenopausal women not only in Western countries but also in Eastern countries, including Japan. Since 1998, when health insurance coverage became available, the number of patients using continuous positive airway pressure (
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