Kyoto University · Medicine
Professor Kazutaka Obama's research lab specializes in molecular oncology, with a primary focus on understanding the genetic and molecular mechanisms underlying cholangiocarcinogenesis, particularly intrahepatic cholangiocarcinoma (ICC). The lab employs advanced genomic technologies such as cDNA microarray analysis and laser microdissection to identify differentially expressed genes and novel molecular targets. Key research directions include the discovery of diagnostic biomarkers and therapeutic targets, with recent work highlighting the role of PSF2 in tumor progression. The lab also investigates colorectal carcinogenesis, aiming to translate molecular insights into novel treatment strategies.
Figures are computed from collected data and may differ slightly.
Early diagnosis of NOMI is possible using the above criteria and MDCT, and initiation of PGE1 treatment may increase survival in patients with NOMI.
Intrahepatic cholangiocarcinoma is a neoplasm arising in the liver, and its incidence is increasing in Japan as well as in Western countries. Prognosis of patients with this type of tumor remains unsatisfactory because no effective chemotherapeutic drugs are available, we have no sensitive tumor markers to detect this tumor in its early stage, and it is difficult to identify a high-risk group for the disease. To clarify the molecular mechanism of tumorigenesis and identify molecular targets for
Our findings may contribute to the better understanding of cholangiocarcinogenesis and open a new avenue to the development of novel therapeutic and/or diagnostic approach to this type of tumor.
To disclose molecular mechanisms of cholangiocarcinogenesis and to search for novel diagnostic markers and therapeutic targets for cholangiocarcinoma, we previously analyzed gene-expression profiles of 25 intrahepatic cholangiocarcinomas (ICCs) by means of a cDNA microarray re-presenting 27,648 genes. Among the genes frequently up-regulated in the cancer cells, we focused on PSF2 (partner of SLD five 2), a component of the GINS multiprotein complex that plays a crucial role in initiation of DNA
The findings reported here may offer new insight into colonic carcinogenesis and contribute to the development of new molecular strategies for treatment of human colorectal tumors.
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