Tohoku University · Medicine
Professor Kenji Fujimori's research lab specializes in radiopharmaceuticals and molecular imaging, focusing on the pharmacokinetics and biodistribution of monoclonal antibodies and their radiolabeled conjugates in cancer and critical care settings. The lab integrates mathematical modeling with clinical data to optimize radioimmunotherapy dosimetry, emphasizing both macroscopic organ distribution and microscopic tumor penetration dynamics. A key research direction involves improving patient selection for therapies such as PMX (hemoperfusion with polymyxin B) in septic shock by analyzing clinical database correlations with disease severity scores. The lab also advances diagnostic imaging techniques, particularly SPECT/CT fusion imaging, for precise localization of gastrointestinal bleeding.
Figures are computed from collected data and may differ slightly.
For successful use of radiolabeled monoclonal antibodies (MAbs) for diagnosis and therapy, it is helpful to understand both global and microscopic aspects of antibody biodistribution. In this study, antibody distribution in a tumor is simulated by splicing together information on global pharmacokinetics: transport across the capillary wall, diffusive penetration through the tumor interstitial space, and antigen-antibody interaction. The geometry simulated corresponds to spherical nodules of dens
In order to understand the pharmacology of monoclonal antibodies and their conjugates, one must consider both global and microscopic aspects of antibody distribution. Here we present an analysis of antibody distribution in tumors based on the following factors: (a) molecular weight and valence of the antibody; (b) global pharmacokinetic profile following i.v. bolus injection; (c) penetration through the vascular wall; (d) diffusive and convective transport through interstitial space in the tumor
Analysis of a large-scale Japanese inpatient database found a significant association between PMX efficacy and baseline SOFA score. This result indicates higher efficacy in patients with medium SOFA scores in the range of 7-12. The result provides a promising hypothesis for selecting appropriate patients for PMX and should be validated in future RCTs.
Accurate dosimetry is essential for the assessment of radioimmunotherapy. Most often studied to date has been the macroscopic dosimetry related to organ and tumor distribution of the radiolabeled antibody, but the question of microscopic dose heterogeneity is also important. To address the latter issue, we have taken an integrated approach to the pharmacology, taking into account whole-body distribution, transcapillary transport, percolation through the tumor interstitial space, antigen-antibody
Analysis of large Japanese databases showed that septic shock patients who received noradrenaline might benefit from PMX treatment.
Although Tc-99m-labeled RBC SPECT is sensitive for detection of intestinal bleeding, it cannot provide a high degree of specific anatomic information. We present a case of intestinal bleeding in which a fused image composed of those from Tc-99m-labeled RBC SPECT and from x-ray CT revealed small intestinal bleeding with specific anatomic information. We believe that the fused image is useful for anatomic localization of gastrointestinal bleeding and helpful for surgical intervention.
Open papers in the app to read, cite, and organize with AI.
