Kyushu University · Biochemistry, Genetics and Molecular Biology
Professor Kenji Hamase's research lab specializes in the development of advanced analytical methodologies, particularly in chiral separation science and bioanalytical chemistry. The lab focuses on the sensitive and selective determination of D-amino acids in biological systems, with applications in neuroscience and clinical diagnostics. Key research directions include the design of innovative HPLC systems—such as 3D-HPLC with multiple column selectivities—for the accurate quantification of biologically relevant D-amino acids in complex matrices like plasma and brain tissues. The lab also investigates the physiological and pathological roles of D-amino acids, especially through the study of enzymes like D-amino acid oxidase in mouse models and human diseases such as chronic kidney disease.
Figures are computed from collected data and may differ slightly.
The determination of small amounts of D-amino acids in mammalian tissues is still a challenging theme in the separation sciences. In this review, various gas-chromatographic and high-performance liquid chromatographic methods are discussed including highly selective and sensitive column-switching procedures. Based on these methods, the distributions of D-aspartic acid, D-serine, D-alanine, D-leucine and D-proline have been clarified in the mouse brain. As the regulation mechanisms of D-amino aci
The concentrations of several d-amino acids have been reported to significantly increase in the plasma of patients with chronic kidney disease (CKD). However, the amounts of these d-amino acids are low (around 1% of the l-form or lower), and their analyses were complicated by various interfering compounds in many clinical samples. A highly selective analytical method is thus required to perform the accurate and precise determination of these d-amino acids in the plasma of CKD patients. In the pr
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