Tohoku University · Engineering
Kenta Aoyagi 교수의 연구실은 식물에서의 이소프레노이드 생합성 경로와 관련된 핵심 효소인 HMGR의 유전자 구조와 발현 조절을 중심으로 연구를 진행하고 있습니다. 특히 밀을 비롯한 식물에서의 HMGR 유전자 가족의 분리 및 비교 유전자 분석을 통해 유전자 기반의 발달 조절 메커니즘을 규명하고자 합니다. 또한, 임상적 응용과도 연결된 소장 림프관확장증의 내 endoscopic 특징을 규명하여 단백질 유출성 장질환의 진단에 기여하고 있습니다.
Figures are computed from collected data and may differ slightly.
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR, EC 1.1.1.34) is a key enzyme in the isoprenoid biosynthetic pathway. We have isolated partial cDNAs from wheat (Triticum aestivum) using the polymerase chain reaction. Comparison of deduced amino acid sequences of these cDNAs shows that they represent a small family of genes that share a high degree of sequence homology among themselves as well as among genes from other organisms including tomato, Arabidopsis, hamster, human, Dros
Six patients with histologically proven intestinal lymphangiectasia were evaluated for the endoscopic features. White villi and/or spots, previously reported as endoscopic findings, were seen. Furthermore, white nodules and submucosal elevations with or without white mucosa were observed. All patients demonstrated the appearance of submucosal elevations. The four characteristic endoscopic features were correlated with histological findings. It is considered that these endoscopic features are of
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