Sungkyunkwan University · Medicine
Keunchil Park 교수의 연구실은 신약 개발과 암 유전체학을 융합한 전임상 및 임상 연구를 중심으로 진행하고 있습니다. 특히 EGFR Exon20ins 돌연변이를 가진 폐암 환자에게 효과적인 치료제인 아미밴티마브의 임상적 유효성과 안전성을 입증하며 정밀의료에 기여하고 있으며, 동시에 전장 게놈 시퀀싱을 활용한 미토콘드리아 게놈의 종양 특성 분석을 통해 암의 발달 기전을 규명하고 있습니다.
Figures are computed from collected data and may differ slightly.
Amivantamab, via its novel mechanism of action, yielded robust and durable responses with tolerable safety in patients with <i>EGFR</i> Exon20ins mutations after progression on platinum-based chemotherapy.
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. Our analysis presents the most definitive mutational landscape of mitochondri
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