Seoul National University · Medicine
Professor Ki-Bong Oh's research lab specializes in natural product chemistry and antimicrobial drug discovery, with a focus on identifying bioactive compounds from marine and terrestrial sources. The lab investigates the structural characterization and biological activities of natural alkaloids and fatty acid derivatives, particularly those exhibiting potent antimicrobial and antifungal properties. Key research directions include the discovery of novel compounds from marine sponges and medicinal plants, such as farnesoic acid and bis(indole) alkaloids, and evaluating their mechanisms of action against drug-resistant pathogens. The lab also employs advanced analytical techniques like HPLC, NMR, and mass spectrometry to isolate and identify bioactive molecules.
Figures are computed from collected data and may differ slightly.
The yeast Candida albicans has a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a budding yeast form and a multicellular invasive filamentous form. This ability has been postulated to contribute to the virulence of this organism. Studies on the morphological transition from a filamentous to a budding yeast form in C. albicans have shown that this organism excretes an autoregulatory substance into the culture medium. This substance was extracte
Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-r
The antifungal activity of Portulaca oleracea extracts against hyphal growth of various fungi was evaluated in real time using an automatic single-cell bioassay system. Target organisms were the filamentous fungi Aspergillus and Trichophyton and the yeast Candida. A colony of test fungi was in contact with the assay medium, or assay medium containing plant extract, in sequence. The antifungal activity of each fraction of P. oleracea was evaluated based on the dynamic hyphal growth response curve
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