Korea Advanced Institute of Science and Technology · Engineering
Professor Ki-Hun Jeong's research lab specializes in nanophotonics, plasmonics, and microfluidic technologies for next-generation biomedical diagnostics and optical devices. The lab focuses on developing advanced nanostructured substrates—such as silver and gold nanoisland arrays on glass nanopillars—for ultra-sensitive, label-free detection using surface-enhanced Raman scattering (SERS) and for enabling ultrafast on-chip polymerase chain reaction (PCR) through plasmonic photothermal heating. By integrating biomimetic optical structures inspired by nature (e.g., moth eyes, firefly lanterns) with nanofabrication and tunable micro-optics, the lab pioneers compact, high-performance systems for point-of-care diagnostics and miniaturized optical components with enhanced functionality and efficiency.
Figures are computed from collected data and may differ slightly.
The enhancement of surface enhanced Raman scattering (SERS) with nanogap-rich silver nanoislands surrounding glass nanopillars at wafer level is reported. High-density hot spots are generated by increasing the number of nanogap-rich nanoislands within a detection volume. The SERS substrate shows a high enhancement factor of over 10(7) with excellent signal uniformity (∼7.8%) and it enables the label-free detection of aqueous DNA base molecules at nanomolar level.
We report a tunable microdoublet lens capable of creating dual modes of biconvex or meniscus lens. The microdoublet lens consists of a tunable liquid-filled lens and a solid negative lens. It can be tuned either by changing the shape of the liquid-filled lens into bi-convex or meniscus or by changing a filling media with different refractive index. The micro-fabrication is based on photopolymer microdispensing and elastomer micromolding methods. The microdoublet lens can provide a solution for m
Advent and fast spread of pandemic diseases draw worldwide attention to rapid, prompt, and accurate molecular diagnostics with technical development of ultrafast polymerase chain reaction (PCR). Microfluidic on-chip PCR platforms provide highly efficient and small-volume bioassay for point-of-care diagnostic applications. Here we report ultrafast, real-time, and on-chip nanoplasmonic PCR for rapid and quantitative molecular diagnostics at point-of-care level. The plasmofluidic PCR chip comprises
Emerging molecular diagnosis requires ultrafast polymerase chain reaction (PCR) on chip for rapid precise detection of infectious diseases in the point-of-care test. Here, we report nanoplasmonic on-chip PCR for rapid precision molecular diagnostics. The nanoplasmonic pillar arrays (NPA) comprise gold nanoislands on the top and sidewall of large-scale glass nanopillar arrays. The nanoplasmonic pillars enhance light absorption of a white light-emitting diode (LED) over the whole visible range due
The surface-enhanced Raman scattering enhancement (SERS) of small molecules spatially entrapped near hot spots by using nanofluidic channels with localized surface plasmon resonance is reported. Small molecules are introduced into the interstitial nanogaps between a silver film over nanospheres and polydimethylsiloxane, which serve as ‘nanofluidic channels.’ The concurrence between nanofluid stagnation points and the hot spots greatly enhances the SERS signals.
Abstract Biological wonders, found in insects such as antireflecting moth eyes, compound eyes in a honey bee, firefly lanterns, and iridescent butterfly wings, inspire human beings for advanced light imaging and illumination technologies. Dazzling advances of micro‐ and nanofabrication technologies allow insect‐inspired structures, for example, artificial compound eyes with a wide field of view and low aberration, bioinspired light‐emitting diode lenses, and structural coloration templates, feat
This work reports an optofluidic SERS chip with plasmonic nanoprobes self-aligned along microfluidic channels. Plasmonic nanoprobes with rich electromagnetic hot spots are selectively patterned along PDMS microfluidic channels by using a Scotch tape removal and oxygen plasma treatment, which also provide the permanent bonding between PDMS and a glass substrate. A silver film with an initial thickness of 30 nm after oxygen plasma treatment creates nanotips and nanodots with a maximum SERS perform
Metal nanoislands as plasmonic materials on various substrates have been widely applied for various applications from biosensing to photonic applications.
Abstract Light‐field imaging has attracted much attention in constructing 3D objects with a simple configuration and capturing all the spatial and directional data in a single photographic exposure. Here, an ultrathin light‐field camera (ULFC) for high contrast and high‐resolution light‐field imaging using a metal–insulator–metal optical absorber based inverted microlens arrays (MIM‐iMLA) is reported. A metal–insulator–metal based optical absorber (MIM‐OA) between microlenses exhibits high light
Scanning MEMS (micro-electro-mechanical system) mirrors are attractive given their potential use in a diverse array of laser scanning display and imaging applications. Here we report on an electrostatic MEMS mirror for high definition and high frame rate (HDHF) Lissajous scanning. The MEMS mirror comprised a low Q-factor inner mirror and frame mirror, which provided two-dimensional scanning at two similar resonant scanning frequencies with high mechanical stability. The low Q inner mirror enable
Point-of-care real-time reverse-transcription polymerase chain reaction (RT-PCR) facilitates the widespread use of rapid, accurate, and cost-effective near-patient testing that is available to the public. Here, we report ultrafast plasmonic nucleic acid amplification and real-time quantification for decentralized molecular diagnostics. The plasmonic real-time RT-PCR system features an ultrafast plasmonic thermocycler (PTC), a disposable plastic-on-metal (PoM) cartridge, and an ultrathin microlen
Biologically inspired biophotonic surfaces with self-antireflection for highly sensitive biosensing and bioimaging are reported. The effective index of large-area glass nanopillar arrays spontaneously meets an antireflection condition when a solution with diverse index surrounds the nanopillars. The bio-inspired biophotonic surfaces enable not only highly intense fluorescence or surface enhanced Raman scattering but also high contrast imaging due to the self-antireflection. As a service to our a
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