The University of Osaka · Biochemistry, Genetics and Molecular Biology
코이치 후카세 교수의 연구실은 항원성 물질인 펩티도글리칸의 구조 기반 면역조절 작용을 규명하고, 이를 응용한 신약 개발을 주요 연구 방향으로 삼고 있습니다. 특히, 박테리아 세포벽의 핵심 구조인 펩티도글리칸의 생합성 및 생물학적 기능을 정밀하게 합성함으로써 면역조절제 및 항암제 후보 물질의 설계에 기여하고 있습니다. 자연물 유래 항암제의 발굴과 합성 전략 개발을 통해 약물 내성과 부작용 문제를 해결하고자 하는 응용 연구도 활발히 진행 중입니다.
Figures are computed from collected data and may differ slightly.
The peptidoglycan (PG) bacterial cell wall glycoconjugate has been well known as a strong immunopotentiator. Partial structures of PG were chemically synthesized for elucidation of precise biological activities. Effective construction of distinct repeating glycans of PG was accomplished by the coupling of a key disaccharide glucosaminyl-beta(1-4)-muramic acid unit. Stereoselective glycosylation of disaccharide units was achieved by neighboring group participation of the N-Troc (Troc = 2,2,2-tric
Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically a
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