The University of Osaka · Medicine
Professor Kōichi Yamamoto's research lab focuses on the pathophysiological roles of the renin-angiotensin system (RAS), particularly angiotensin-converting enzyme 2 (ACE2) and its ligand angiotensin 1-7, in cardiovascular and metabolic diseases. The lab investigates how RAS components modulate cardiac function under stress conditions such as pressure overload, as well as their influence on insulin resistance and inflammation in adipose tissue and the gut. Additional research explores the interplay between oxidized LDL, LOX-1, and angiotensin II type 1 receptor signaling in vascular dysfunction, and the role of aging-related factors like PAI-1 in thrombotic disease. The lab integrates molecular biology, animal models, and cellular signaling to uncover novel therapeutic targets in cardiovascular and metabolic disorders.
Figures are computed from collected data and may differ slightly.
Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase that cleaves angiotensin II to angiotensin 1-7. Recently, it was reported that mice lacking ACE2 (ACE2(-/y) mice) exhibited reduced cardiac contractility. Because mechanical pressure overload activates the cardiac renin-angiotensin system, we used ACE2(-/y) mice to analyze the role of ACE2 in the response to pressure overload. Twelve-week-old ACE2(-/y) mice and wild-type (WT) mice received transverse aortic constriction (TAC) or sham o
Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD.
Thrombotic cardiovascular diseases increase in incidence in the elderly, a tendency dependent on the age-related changes in vascular and hemostatic systems that include platelets, coagulation, and fibrinolytic factors as well as in the endothelium. The hypercoagulability of and advanced sclerotic changes in the vascular wall may contribute to the increased incidence of thrombosis in the elderly. One of the important key genes for aging-associated thrombosis is plasminogen activator inhibitor-1 (
l.-Introduction.-Theproblem to determine the order $f(n)$ of the free distributive lattice $FD(n)$ generated by $n$ symbols $\gamma_{1},$ $\cdots,$ $\gamma_{n}$ was first proposed by Dedekind, but very little is known about this number [1, p. 146].Only the first six values of $f(n)$ are computed, and enumerations of further $f(n)$ appear to lie beyond the scope of any reasonable methods known today.It might, however, be pointed out that Morgan Ward, who found $f(6)$ by the help of computing mach
Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin-angiotensin system (RAS), ACE2 cleaves angiotensin II (Ang II) into angiotensin 1-7 (Ang 1-7), which is considered to exert cellular responses to counteract the activation of the RAS primarily through a receptor, Mas, in multiple organs including skeletal muscle. Previous studies have provided abundant evidence suggesting that Ang
The angiotensin II type 1 receptor (AT1) is a 7-transmembrane domain GPCR that when activated by its ligand angiotensin II, generates signaling events promoting vascular dysfunction and the development of cardiovascular disease. Here, we show that the single-transmembrane oxidized LDL (oxLDL) receptor (LOX-1) resides in proximity to AT1 on cell-surface membranes and that binding of oxLDL to LOX-1 can allosterically activate AT1-dependent signaling events. oxLDL-induced signaling events in human
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