The University of Osaka · Medicine
Professor Kotaro Yamashita's research lab specializes in surgical oncology with a focus on improving outcomes for patients with esophageal and pancreatic cancers. The lab investigates multimodal treatment strategies, including curative-intent surgery and lymph node dissection techniques, to enhance survival and reduce postoperative complications. Key research directions include predicting postoperative pneumonia through preoperative oropharyngeal cultures and evaluating the impact of extended lymphadenectomy in esophageal squamous cell carcinoma. The lab also explores the prognostic significance of metastatic patterns, particularly isolated pulmonary metastasis in pancreatic ductal adenocarcinoma, and the role of surgical resection in improving survival.
Figures are computed from collected data and may differ slightly.
Although the prognosis of recurrent esophageal cancer remains unfavorable, if multimodal treatment that includes local therapy was curative, prognosis could improve, especially in patients with lymph node or lung recurrence.
Patients with first recurrence of PDAC as pulmonary metastasis had a better prognosis than patients with other types of metastases. Moreover, when isolated pulmonary metastasis is controlled for a certain period, pulmonary resection is likely to improve patient survival.
Preoperative oropharyngeal culture is a simple and low-cost method that can predict both the occurrence of postoperative pneumonia and poor prognosis after esophagectomy.
Although 3-field lymph node dissection (3-FLD) is often performed for thoracic esophageal squamous cell carcinoma (ESCC), the clinical effects of cervical lymph node dissection in addition to mediastinal and abdominal dissections on postoperative complications remain unclear. A total of 367 ESCC patients who underwent curative esophagectomy for thoracic esophageal cancer in our hospital from 2010 to 2015 were included in the study: 157 patients who underwent 2-field lymph node dissection (2-FLD)
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