Hokkaido University · Medicine
Professor Kumiko Yoshimatsu's research lab focuses on molecular oncology and cancer biology, with a particular emphasis on identifying novel antitumor agents and understanding the role of key enzymes in carcinogenesis. The lab investigates sulfonamide-based compounds like E7010 as potential anticancer therapeutics and explores the enzymatic pathways involving prostaglandin E synthase and cyclooxygenase-2 in non-small cell lung cancer. Additionally, the lab contributes to understanding the pathogenesis of chronic kidney disease of unknown aetiology (CKDu), especially in endemic regions like Sri Lanka. Their work integrates biochemical, cellular, and translational approaches to uncover disease mechanisms and develop targeted therapies.
Figures are computed from collected data and may differ slightly.
E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonami de), an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial, showed rather consistent growth-inhibitory activities against a panel of 26 human tumor cell lines (IC50 = 0.06-0.8 microg/ml), in contrast to vincristine (VCR; IC50 = 0.0002-0.04 microg/ml), 5-fluorouracil (IC50 = 0.2-30 microg/ml), Adriamycin (IC50 = 0.002-0.7 microg/ml), mitomycin C (IC50 = 0.007-3 microg/ml), 1-beta-D-ara
An inducible microsomal form of human prostaglandin E synthase (mPGES) was recently identified. This enzyme converts the cyclooxygenase (COX) product, prostaglandin (PG) H2, to PGE2, a prostanoid that has been implicated in carcinogenesis. Increased amounts of PGE2 are detected in many types of cancer, but the underlying mechanism is not fully understood. Hence, we compared amounts of mPGES in 19 paired samples (tumor and adjacent normal tissue) of non-small cell lung cancer (NSCLC). By immunobl
Chronic kidney disease (CKD) is recognized as a major public health problem worldwide and in South Asia including Sri Lanka.1Mishra S. Adhikari S. Sigdel M. Nedkoff L. Briffa T. Chronic kidney disease in South Asia.Lancet Glob Health. 2016; 4: e523Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar Initially reported in the 1990s, the health authorities of the dry zone areas of Sri Lanka have identified a high prevalence of CKD in cases without known risk factors. This new form of
Multimerization of the Hantaan virus nucleocapsid protein (NP) in Hantaan virus-infected Vero E6 cells was observed in a competitive enzyme-linked immunosorbent assay (ELISA). Recombinant and truncated NPs of Hantaan, Seoul, and Dobrava viruses lacking the N-terminal 49 amino acids were also detected as multimers. Although truncated NPs of Hantaan virus lacking the N-terminal 154 amino acids existed as a monomer, those of Seoul and Dobrava formed multimers. The multimerized truncated NP antigens
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