Yonsei University · Medicine
Professor Kyung Soo Chung's research lab focuses on translational biomedical research with a strong emphasis on extracellular vesicles, particularly exosomes, as innovative therapeutic delivery systems for inflammatory and autoimmune diseases. The lab pioneers optogenetic engineering of exosomes to enhance cargo loading—demonstrated through the delivery of super-repressor IκB to modulate NF-κB signaling and attenuate systemic inflammation. Additional research explores the role of lipid metabolism, such as triglyceride levels, in critical illness and sepsis outcomes, as well as the pathogenesis of systemic lupus erythematosus with a focus on thoracic and coagulation disorders. The lab integrates molecular biology, immunology, and clinical translational approaches to develop novel biologics and diagnostic insights.
Figures are computed from collected data and may differ slightly.
As extracellular vesicles that play an active role in intercellular communication by transferring cellular materials to recipient cells, exosomes offer great potential as a natural therapeutic drug delivery vehicle. The inflammatory responses in various disease models can be attenuated through introduction of super-repressor IκB (srIκB), which is the dominant active form of IκBα and can inhibit translocation of nuclear factor κB into the nucleus. An optogenetically engineered exosome system (EXP
Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.
Thoracic involvement occurs more frequently in systemic lupus erythematosus than in any other connective tissue diseases, and more than half of patients with the disease suffer from the involvement. Primary intrathoracic manifestations include pleural disease (effusions and/or thickening), acute lupus pneumonitis, subacute interstitial lung disease including bronchiolitis obliterans organizing pneumonia and non-specific interstitial pneumonia with fibrosis, chronic interstitial lung disease of u
An 18-month-old child, who had no evidence of liver disease, malabsorption, or chronic ingestion of coumarin compounds, was found to have plasma deficiencies of factors II, VII, IX and X. Assays for factor II and X by immunological techniques (antibody neutralization and immunoelectrophoresis) revealed normal or elevated antigenic activity of these factors, suggesting the presence of abnormal protein variants in the patient's plasma. On two-dimensional immunoelectrophoresis of the patient's plas
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