Kyung Hee University · Biochemistry, Genetics and Molecular Biology
Kyung-Tae Lee 교수의 연구실은 천연물에서 유래한 사포닌 및 이소플라보노이드 등 생활물질의 생리활성 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 특히 염증 반응 조절, 항산화 작용, 항암 및 항유전자변형 작용을 보이는 화합물의 분자 기전을 연구하며, 만성 염증성 질환과 암 예방에 기여할 수 있는 신약 후보 물질 개발을 목표로 하고 있습니다. 다양한 식물에서 분리된 사포닌과 폴리페놀 화합물의 생물학적 기전을 체계적으로 분석하고 있습니다.
Figures are computed from collected data and may differ slightly.
Buddlejasaponin IV isolated from Pleurospermum kamtschatidum is an anti-inflammatory compound that inhibits NO, PGE(2) and TNF-alpha production. Here, we studied the mode of action of this compound. Buddlejasaponin IV (2.5-10 microM) reduced lipopolysaccaride (LPS (1 microg ml(-1)))-induced levels of iNOS and COX-2 at the protein levels, and iNOS, COX-2, TNF-alpha, interleukin (IL)-1beta and IL-6 mRNA expression in RAW 264.7 macrophages in a concentration-dependent manner, as determined by Weste
For the elucidation of the antimutagenic and cytotoxic principles from the stem bark of Kalopanax pictus, seven isolated components of this crude drug were tested in the Ames test and the MTT test. Hederagenin and its monodesmosides, kalopanaxsaponin A and I in addition to its bisdesmosides, kalopanaxsaponin B and H, showed potent antimutagenic activities against aflatoxin B1 (AFB1). However, they had no inhibitory effects on mutagenicity induced by the direct mutagen, N-methyl-N'-nitro-N-nitros
We isolated a new saponin named codonoposide (1) from the roots of Codonopsis lanceolata (Campanulaceae) and characterized it as 3-O-[beta-D-xylopyranosyl(1-3)-beta-D-glucuronopyranosyl]-3beta,16alpha-dihydroxyolean-28-oic acid 28-O-[beta-D-xylopyranosyl (1-3)-alpha-L-rhamnopyranosyl (1-2)-alpha-L-arabinopyranosyl] ester by chemical, physicochemical, and 2DNMR techniques. Complete hydrolysis of 1 produced a sapogenin (1a), and the partial hydrolysis and further isolation afforded two prosapogeni
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