Sungkyunkwan University · Medicine
Professor Kyu-Sung Lee's research lab specializes in urological disorders, with a focus on lower urinary tract symptoms, including overactive bladder (OAB), underactive bladder (DUA), and stress urinary incontinence. The lab investigates innovative surgical and medical therapies, such as mid-urethral slings and combination pharmacotherapies, while also pioneering bio-integrated electronic systems that mimic the dynamic behavior of the urinary bladder. Their work bridges clinical urology with advanced biomedical engineering, particularly in developing implantable, conformal electronic devices for real-time bladder monitoring and functional restoration.
Figures are computed from collected data and may differ slightly.
This study reveals that combination therapy consisting of alpha1-adrenoceptor antagonists with antimuscarinics represents an effective and relatively safe treatment modality in select patients with OAB coexisting with benign prostatic obstruction.
The repeat mid urethral sling for persistent or recurrent stress urinary incontinence has a lower cure rate than the initial sling. However, the retropubic approach tends to have a higher cure rate than the transobturator approach in repeat sling cases.
The tension-free vaginal tape and transobturator vaginal tape inside-out procedures were minimally invasive and similar in operation related morbidity. Transobturator vaginal tape inside-out appeared to be as effective and safe as tension-free vaginal tape for the surgical treatment of stress urinary incontinence in women at 1-year followup.
Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with
These results support the hypothesis that OAB in a subgroup of depressed individuals may be associated with altered 5-HT function. It may explain reports of an association between depression and OAB.
ClinicalTrials.gov identifier: NCT02618421 , registered 26 November 2015 (retrospectively registered).
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