Tokyo Institute of Technology · Biochemistry, Genetics and Molecular Biology
M. Michael Gromiha 교수의 연구실은 단백질 안정성과 접힘 메커니즘을 중심으로 하는 생물정보학 및 구조 생물학 분야에서 활발한 연구를 수행하고 있습니다. 단백질의 열적 안정성, 돌연변이에 의한 안정성 변화 예측, 접힘 속도 예측 등 단백질의 열역학적 성질을 정량적으로 분석하는 데 초점을 맞추고 있으며, ProThermDB와 같은 핵심 데이터베이스 구축을 통해 분야 기여도가 높습니다. 특히, 아미노산 성질과 단백질 안정성 간의 상관관계를 규명하고, 열성 단백질의 안정성 원리를 규명하는 데에도 기여하고 있습니다.
Figures are computed from collected data and may differ slightly.
Click to increase image sizeClick to decrease image size AcknowledgementsWe thank the Department of Biotechnology and Indian Institute of Technology Madras for computational facilities. We wish to acknowledge Dr. C. Ramakrishnan, Dr. S. Anusuya, S. Akila Parvathy Dharshini and Dr. A. Mary Thangakani for fruitful discussions.Disclosure statementNo potential conflict of interest was reported by the authors.TableDownload CSVDisplay TableAdditional informationFundingThe work is partially supported b
Abstract ProThermDB is an updated version of the thermodynamic database for proteins and mutants (ProTherm), which has ∼31 500 data on protein stability, an increase of 84% from the previous version. It contains several thermodynamic parameters such as melting temperature, free energy obtained with thermal and denaturant denaturation, enthalpy change and heat capacity change along with experimental methods and conditions, sequence, structure and literature information. Besides, the current versi
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