Tohoku University · Medicine
Professor Makoto Ohta's research lab focuses on tumor microenvironment interactions, particularly the role of macrophages in cancer angiogenesis across gastrointestinal malignancies such as esophageal and gastric carcinomas. The lab investigates molecular mechanisms involving chemokines like MCP-1/CCR2 and angiogenic factors such as VEGF, using clinical specimens and cell line models to elucidate tumor-stroma crosstalk. Additionally, the lab explores biomaterials for medical simulation, developing tissue-mimicking phantoms with optimal mechanical and imaging compatibility for vascular and hemodynamic studies. These interdisciplinary efforts bridge cancer biology, translational medicine, and biomedical engineering.
Figures are computed from collected data and may differ slightly.
Tumor angiogenesis requires the production of angiogenic factors by tumor and stromal cells. Macrophages are key effectors of angiogenesis and reported to contribute to tumor angiogenesis in several carcinomas. To investigate interactions between tumor cells and macrophages in angiogenesis, we examined macrophage infiltration, tumor vascularity and expression of monocyte chemoattractant protein (MCP)-1, CC chemokine receptor 2 (CCR2) and vascular endothelial growth factor (VEGF) in 57 archival s
The purpose of this study was to investigate the role of interactions between tumor cells and macrophages during angiogenesis in human gastric carcinomas. Macrophage infiltration into tumors and monocyte chemoattractant protein-1 (MCP-1) expression was assessed in 72 archival specimens of gastric carcinoma for comparison with tumor vascularity. The mRNA expression of MCP-1 was examined by RT-PCR in 6 gastric carcinoma cell lines and in fresh biopsy specimens from 18 patients. Immunolocalization
Did the 1973 and 1979 gasoline price rises change consumer views about the relative quality of different cars? This question is investigated by testing the null hypothesis that imputed characteristic prices have re- mained constant over time. A hedonic model that takes gasoline costs into account is developed and some of its theoretical implications are outlined.
Both model types were transparent and compatible with current medical imaging methods. PVA-H models exhibited much lower friction characteristics. PVA-H stiffness was closer to soft tissue when compared to silicone, allowing for pulsations during flow simulations.
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