The University of Osaka · Medicine
Professor Manabu Fujimoto's research lab specializes in autoimmunity, with a focus on identifying and characterizing autoantibodies in autoimmune diseases such as dermatomyositis and the anti-synthetase syndrome. The lab investigates the pathogenic mechanisms underlying these conditions, particularly the role of anti-ARS and anti-TIF-1 antibodies in linking autoimmunity to cancer-associated immune responses. Using serological and molecular approaches, the lab aims to classify autoimmune subtypes based on autoantibody profiles to improve diagnosis, prognosis, and personalized treatment strategies.
Figures are computed from collected data and may differ slightly.
Patients with anti-ARS Abs are relatively homogeneous. However, the distribution and timing of myositis, ILD, and rashes differ among patients with individual anti-ARS Abs. Thus, identification of individual anti-ARS Abs is beneficial to define this rather homogeneous subset and to predict clinical outcomes within the "anti-synthetase syndrome."
This novel MSA is associated with cancer-associated DM and may serve as a diagnostic serological marker for this specific subset.
Anti-155/140 antibodies target TIF-1 family proteins, TIF-1α and TIF-1β, in addition to TIF-1γ. Since TIF-1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity.
'Autoantibody-based classification' of dermatomyositis subsets is now a useful strategy for comprehending the heterogeneous spectrum of dermatomyositis.
Ligation of the B cell Ag receptor (BCR) induces cellular activation by stimulating Src-family protein tyrosine kinases (PTKs) to phosphorylate members of the BCR complex. Subsequently, Src-family PTKs, particularly Lyn, are proposed to phosphorylate and bind CD19, a cell-surface costimulatory molecule that regulates mature B cell activation. Herein, we show that B cells from CD19-deficient mice have diminished Lyn kinase activity and BCR phosphorylation following BCR ligation. Tyrosine phosphor
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