Kyoto University · Engineering
Professor Masahiro Inoue's research lab specializes in asymmetric catalysis and molecular design, with a strong focus on developing novel chiral ligands for transition metal-catalyzed enantioselective reactions—particularly in allylation, methallylation, and propargylation. The lab also explores fundamental electromagnetic phenomena in plasmonic nanostructures, especially the optical properties of metal cluster systems, with applications in surface-enhanced Raman spectroscopy. Additionally, the lab investigates biological mechanisms in orthopedic biomechanics and cancer dormancy, integrating experimental and theoretical approaches to understand joint stability and tumor cell quiescence. These diverse yet interconnected research directions reflect a commitment to advancing both synthetic methodology and the understanding of complex chemical and biological systems.
Figures are computed from collected data and may differ slightly.
This work describes the development of a new tridentate ligand effective for the asymmetric catalysis of Nozaki-Hiyama allylation and methallylation. Various aldehydes were allylated or methallylated with good enantioselectivity (86-96%), and a key intermediate of calcitriol lactone synthesis was also obtained with excellent diastereoselectivity (97% de, 91%). The enantioselective reaction catalyzed by this Cr-ligand complex is applicable to a broad range of aldehydes and has great potential for
An electromagnetic theory for the light absorption by a cluster of metal spheres and the Raman scattering by a molecule adsorbed on it is presented, which takes into account the retardation effect exactly and is applicable to an arbitrary cluster size. The theory is applied to a two-sphere cluster of Ag and Au. It is shown that the absorption spectrum is doubly peaked and the maximum enhancement factor of the Raman intensity amounts to 10 7 ∼10 8 when the distance between spheres is decreased. A
The purpose of this study was to explain the functional roles of the medial collateral ligament (MCL) and the ACL and how they affect the kinematics of the knee joint after isolated MCL injury. Varus-valgus joint laxity was quantitatively measured using a device which allowed various degrees of freedom (DOF) of joint motion during application of a varus-valgus bending moment to the canine knee joint. When the knee motion was limited to 3 DOF (varus-valgus rotation, proximal-distal, and medial-la
The idea of tumor dormancy originated from clinical findings that recurrence of cancer occurs several years or even several decades after surgical resection of the primary tumor. Tumor mass dormancy was proposed as a model, where there is equal balance between increases in the number of cancer cells by proliferation and decreases as a result of cell death. Tumor mass dormancy includes angiogenic dormancy and immune-mediated dormancy. Another emerging type of tumor dormancy is cellular dormancy i
Abstract For Abstract see ChemInform Abstract in Full Text.
Catalytic asymmetric Nozaki-Hiyama propargylation with ligand 1c proceeds with good to excellent enantioselectivity. Tuning of ligand 1 dramatically changes the enantioselectivity, and we propose models A and B to explain the change and outcome of the enantioselectivity.
From aldehydes to allenic alcohols: Studies into the asymmetric catalysis of the Nozaki–Hiyama allenylation are described. Ligand 1 a is effective for the enantioselective allenylations of various aldehydes, with the generation of products with ee values ranging from 72–83 %. The products can be easily desilylated or used as allenylsilanes. DIPEA=diisopropylethylamine, DMI=1,3-dimethyl-2-imidazolidinone, DMS=dimethylsilyl, TMS=trimethylsilyl. Supporting information for this article is available
The optical reflectivity from a monolayer of regularly arrayed dielectric spheres is calculated. It is shown that the structures of the reflectivity curve are classified into three groups: a broad background, fine structures at the channel thresholds, and a group of sharp peaks. the first two groups are attributed to the interference effect in an effective slab and the resonance anomaly in the multichannel scattering, respectively. The third is found to arise due to coupling with new modes, elec
The long-term effects of surgical repair and immobilization on the healing of the transected medial collateral ligament (MCL) were studied biomechanically, biochemically and histologically in a canine model. Twelve adult canines were divided into two experimental groups and studied at 48 weeks postoperatively. For Group I, the transected MCL of the left knee was not repaired, and the joint was not immobilized. For Group II, the MCL was repaired and the joint was immobilized for six weeks. The ri
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