Tohoku University · Medicine
Professor Masaki Nio's research lab specializes in pediatric surgical oncology and hepatobiliary surgery, with a primary focus on biliary atresia and rare pediatric abdominal tumors. The lab investigates surgical outcomes, optimal timing for Kasai portoenterostomy, and long-term survival in children with biliary atresia, drawing on extensive clinical data from national registries. They also explore minimally invasive surgical techniques, such as thoracoscopic surgery, for pediatric neoplasms. The lab's work emphasizes improving surgical strategies and long-term outcomes in pediatric patients with complex hepatobiliary conditions.
Figures are computed from collected data and may differ slightly.
There are discrepancies regarding the clinical impact of age at Kasai portoenterostomy (KP) on surgical outcomes. Hence, we re-assessed the clinical significance of age at KP. We analyzed 224 patients with type III (atresia of bile duct at the porta hepatis) biliary atresia at Tohoku University Hospital. We classified patients into two groups: KP at ≤60 days of age (group TE) and >60 days of age (group TL). Group TE was subdivided into three groups (TE1, TE2, and TE3) according to age at time of
Between 1953 and 1995, 300 patients with biliary atresia underwent surgery at Tohoku University Hospital. The 10-year survival of patients who were operated on in or before 1965 was 9%. But the survival rate went up to 61% in patients operated on between 1976 and 1985. Eighty-five patients including 2 who developed liver failure after Kasai operation and underwent liver transplantation have survived more than 10 years. Eleven of them (13%) have recurrent or persistent jaundice. Of the 30 patient
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